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Diss Factsheets
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EC number: 230-039-0 | CAS number: 6921-34-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
Key value for chemical safety assessment
Effect on neurotoxicity: via inhalation route
Link to relevant study records
- Endpoint:
- neurotoxicity: acute inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- other: Reliability score is not applicable because available data are on stabilizer agent (as described in sect. 1.2) and not on the benzylmagnesium chloride as such.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: U. S. EPA, Toxic substances Control Act Health Effects Testing guideline, 40 CFR Part 798 Subpart G, Neurotoxicity (1985) and USEPA/FIFRA Neurotoxicity Pesticide Assessment Guidelines F, PB 91-154617 (1991)
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- other: Crl:CD BR
- Sex:
- male/female
- Route of administration:
- inhalation: vapour
- Vehicle:
- other: air distribution line
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 6h
- Frequency of treatment:
- single exposure
- Remarks:
- Doses / Concentrations:
0, 500 ppm, 2500 ppm, 5000 ppm
Basis: - No. of animals per sex per dose:
- 12
- Control animals:
- yes
- Dose descriptor:
- NOAEC
- Effect level:
- 500 ppm
- Sex:
- male/female
- Basis for effect level:
- other: The most relevant effect of acute inhalation exposure of THF is a transient sedation with exposure concentrations of 2500 ppm and 5000 ppm
- Remarks on result:
- other:
- Conclusions:
- Groups of male and female rats received tetrahydrofuran inhalation exposure at concentrations of 0, 500, 2500 and 5000 ppm. The principal neurobehavioral effects of exposure to 1500 ppm or greater is acute behavioral sedation which dissipates rapidly after termination of exposure. Clinical observations, motor activity tests, and functional observational battery assessments conducted on the day following acute exposure did not reveal indications of continuing sedation. Two effects of acute THF exposure that were evident one day after exposure involved slightly increased motor activity and altered body weight change for 5000 ppm males. Acute exposure of rats to 500 ppm had no identifiable effects during or after exposure.
- Executive summary:
In this study, four groups of 12 male and 12 female Crl:CD BR rats received tetrahydrofuran acute (6 hours) exposure through inhalation at concentrations 0, 500, 2500 and 5000 ppm. Evaluations conducted immediately after exposure included clinical observations, motor activity assessments (MA), and a battery of functional tests (FOB) designed to reveal nervous system dysfunction. During exposure to 2500 and 5000 ppm, rats had a diminished or absent startle response to a punctate auditory alerting stimulus.
Following exposure to 5000 ppm, male and female rats were lethargic, exhibited abnormal gait or mobility, and splayed rear feet. Lethargy and splayed rear feet were also observed in females esposed to 2500 ppm. During the subsequent FOB, males exposed to 5000 ppm had a lower incidence of palpebral closure, higher incidences of slow or absent righting reflex, and a biphasic pattern of reduced motor activity followed by increased motor activity. Females exposed to 5000 ppm had increased incidences of palpebral closure in the open field, increased incidences of slow or absent righting reflex, and decreased motor activity.
Post-exposure clinical observations and neurobehavioral assessments indicated that THF’s sedative properties waned rapidly after termination of exposure. Acute exposure of rats to 500 ppm had no identifiable effects during or after exposure. The demonstrated no-observed-effect level of tetrahydrofuran exposure is 500 ppm.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 1 500 mg/m³
- Species:
- rat
Additional information
Justification for classification or non-classification
Acute inhalation toxicity
On the basis of CNS depression effects on animal studies, tetrahydrofuran has to be classified as R67 under the EU DSD classification criteria. Due to upper respiratory tract irritation in animal studies, tetrahydrofuran has to be classified as Xi;R37 under the EU DSD classification criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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