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EC number: 429-990-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1998-09-01 to 1999-01-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study is regarded as relaible without restrictions because it was conducted in compliance with GLP regulaiton and guideline.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- cited as : Directive 92/69/EEC
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L
- Sampling method: Aqueous samples were taken from the test medium to determine the concentration of the major breakdown product of Incozol LV. Samples were taken at the start and end of the exposure period. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The 100 mg/L test medium was prepared by direct addition of Incozol LV to dilution water. The test medium was stirred using a magnetic stirrer for approximately 2 h before addition to the test vessels. Following addition of the D. magna the test vessels were sealed. A control treatment was prepared containing dilution water only. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: The test was carried out using a single clone of Daphnia magna cultured at Covance.
- Age at study initiation: <= 24 hours
- Food type: unicellular green algae, Ankistrodesmus falcatus (4E+07 cells/mL)
- Amount: 2 mL per vessel
- Frequency: daily - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 170 mg/L CaCO3
- Test temperature:
- 19.4 ± 1 °C
- pH:
- Control : 7.0
100 mg/L : 8.0 - Dissolved oxygen:
- control : 98 (% air saturated value)
100 mg/L: 95 (% air saturated value) - Nominal and measured concentrations:
- Nominal concentration: 100 mg/L
No measured concentration. - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass conical flask
- Type: closed
- Material, size, headspace, fill volume: containing approximately 120 mL of test medium when fully filled.
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: daily 16 h photoperiod.
TEST CONCENTRATIONS
A limit test was conducted with 100 mg/L test item concentration. - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-h LC50 was determined to be greater then 100 mg/L and the 48-h NOEC was determined to be greater then 100 mg/L.
- Executive summary:
A study was conducted according to OECD TG 202 and Directive 92/69/EEC method C.2 to determine the acute toxicity of Incozol LV to aquatic invertebrates. The study was conducted as limit test. Therefore, a solution with concentration of 100 mg/L test item was prepared by direct addition of Incozol LV to dilution water; the test medium was stirred for approximately 2 h before addition to the test vessels. Following addition of the D. magna the test vessels were sealed. A control treatment was prepared containing dilution water only. No immobility of D. magna was observed, accordingly, the 24- and 48-h EC50 values of Incozol LV were determined to be > 100 mg/L.
Reference
Description of key information
The acute toxicity of Incozol LV to Daphnia magna was determined after 48-h as LC50 to be greater than 100 mg/L and the 48-h NOEC was determined to be greter than 100 mg/L, respectively.
Key value for chemical safety assessment
Additional information
A study was conducted according to OECD TG 202 and Directive 92/69/EEC method C.2 to determine the acute toxicity of Incozol LV to aquatic invertebrates. The study was conducted as limit test. Therefore, a solution with concentration of 100 mg/L test item was prepared by direct addition of Incozol LV to dilution water; the test medium was stirred for approximately 2 h before addition to the test vessels. Following addition of the D. magna the test vessels were sealed. A control treatment was prepared containing dilution water only. No immobility of D. magna was observed, accordingly, the 24- and 48-h EC50 values of Incozol LV were determined to be > 100 mg/L.
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