Registration Dossier
Registration Dossier
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EC number: 700-320-7 | CAS number: 18916-17-1
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-11-27 to 2008-12-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- , 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- , 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2006-06-01
- Type of method:
- flask method
Test material
- Reference substance name:
- 1-(4-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
- EC Number:
- 700-320-7
- Cas Number:
- 18916-17-1
- Molecular formula:
- C27H34O14
- IUPAC Name:
- 1-(4-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
- Reference substance name:
- 1-[4-[[2-O-(6-Deoxy-L-mannopyranosyl)-D-glucopyranosyl]oxy]-2,6-dihdroxyphenyl]-3(4-hydroxyphenyl)-1-propanone
- IUPAC Name:
- 1-[4-[[2-O-(6-Deoxy-L-mannopyranosyl)-D-glucopyranosyl]oxy]-2,6-dihdroxyphenyl]-3(4-hydroxyphenyl)-1-propanone
- Details on test material:
- - Name of test material (as cited in study report): Naringin dihydrochalcone (DHC)
- Physical state: solid, whitish powder
- Storage condition of test material: room temperature, dry and dark
No further details are given.
Constituent 1
Constituent 2
Results and discussion
Water solubilityopen allclose all
- Water solubility:
- 0.111 g/L
- Temp.:
- 10 °C
- pH:
- 4
- Water solubility:
- 0.116 g/L
- Temp.:
- 10 °C
- pH:
- 6.96
- Water solubility:
- 0.735 g/L
- Temp.:
- 10 °C
- pH:
- 8.49
- Water solubility:
- 0.236 g/L
- Temp.:
- 20 °C
- pH:
- 4
- Water solubility:
- 0.273 g/L
- Temp.:
- 20 °C
- pH:
- 6.98
- Water solubility:
- 1.33 g/L
- Temp.:
- 20 °C
- pH:
- 8.46
- Water solubility:
- 0.493 g/L
- Temp.:
- 30 °C
- pH:
- 3.93
- Water solubility:
- 0.59 g/L
- Temp.:
- 30 °C
- pH:
- 6.98
- Water solubility:
- 2.66 g/L
- Temp.:
- 30 °C
- pH:
- 8.47
- Details on results:
- A temperature and pH dependence of the solubility of the test item was observed. The solubility was higher at higher temperatures and pH values. For details see attachments.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): moderately soluble (100-1000 mg/L) at 20°C and pH 7: 273 mg/L
A temperature and pH dependence of the solubility of the test item was observed. For details see attachments.
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