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EC number: 223-423-4 | CAS number: 3886-69-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Exposure based adaptation of information requirements:
According to REGULATION (EC) No 1907/2006, Annex VIII, repeated dose toxicity testing (section 8.6) may be omitted, if relevant human exposure can be excluded in accordance with Annex XI section 3. Furthermore and in accordance with section 3.2 (b) of Annex XI (as amended by Regulation 134/2009), testing for repeated dose toxicity can be omitted when the substance is not incorporated in an article and the manufacturer can demonstrate and document for all relevant scenarios that throughout the life cycle strictly controlled as well as rigorously contained conditions as set out in Article 18(4)(a) to (f) (Regulation 1907/2006) apply.
Life-cycle stage(s) covered:
1. Manufacture of substance (PROCs 1, 2, 3)
2. Formulation and charging and discharging of substances and mixtures (PROCs 1, 2, 3, 8b, 9)
3. Use in industrial chemical processes (PROCs 1, 2, 3, 8b, 9, 15)
4. Use as intermediate (PROCs 1, 2, 3)
Classification:
H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H314: Causes severe skin burns and eye damage.
The substance is harmful after single ingestion and after a single dermal application. Additionally, the substance is corrosive. Based on the bacterial reverse mutation assay and the HPRT assay D-alpha-methylbenzylamine is
not considered to induce gene mutations neither in the absence nor in the presence of a metabolic activation system. A micronucleus test in vivo will be conducted to clarify the results of the in vitro micronucleus assay. For reasons of occupational health and safety, the study has already been ordered with the read across substance DL-alpha-methylbenzylamine (CAS No. 618-36-0). Therefore, no final evaluation of genetic toxicity of the test substance is currently made.
Process description:
After manufacturing D-alpha-methylbenzylamine (CAS No. 3886-69-9) is either formulated or used as an intermediate or used in industrial chemical processes such as being a supplement during enantiomeric separation. The use conditions of D-alpha-methylbenzylamine throughout the whole life cycle of the substance are regarded to be completely strictly controlled and/or rigorously contained according to REACH article 18(4), leading to no significant exposure.
Additionally, a small, well-defined and trained group of workers is exposed occasionally to low levels using appropriate risk management measures to minimize exposure.
Rigorous containment measures:
The substance is manufactured and used under strictly controlled conditions over the entire lifecycle. Exposure is limited to occasional sampling tasks for quality control, as well as to charging and discharging processes. Transport, storage tanks, reactors, processing equipment, and feeds operate in fully closed systems.
Procedural and control technologies are used to minimise residual emissions/exposure as well as qualitative risk considerations:
Operational and technical conditions and measures affecting and controlling workers exposure, such as local exhaust ventilation as well as personal protective equipment, such as goggles, chemically resistant gloves, and respiratory protection where potential exposure may occur as reported in the CSR are followed (see chapters 9 & 10).
Additionally, measures following the qualitative risk assessment performed for local dermal exposure as reported in the CSR are considered.
On the basis of the described process conditions, a testing of D-alpha-methylbenzylamine in a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD 422) study was not performed since the criteria of exposure based adaptation of information requirements are met.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
See endpoint "effects on fertility".
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.