Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-101-0 | CAS number: 12068-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: The concentrations of the metallic elements in all test groups were analyzed in all test concentrations of the when freshly prepared and the aged media. One test vessel was selected from each test vessel (i.e. replicate) randomly. One 10 mL-test sample taken from this test vessel were used to analyze the concentrations of the metallic elements.
- Sample storage conditions before analysis: The samples were stored at 5±3℃ - Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
According to the WSFs (water soluble fractions) method, loading rates of 0.190, 0.430, 0.900, 2.10, 4.50 and 10.0 mg/L were prepared and stirred (using a magnetic stirrer) in the dark for 72 h at 700 rpm. The media were then filtered using a 0.45 μm nitrocellulose membrane. - Test organisms (species):
- Daphnia magna
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Hardness:
- 140 - 170 mg/L
- Test temperature:
- 19.8 - 20.3 °C
- pH:
- 7.0 - 7.9
- Dissolved oxygen:
- 8.11 - 9.20 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 0.190, 0.430, 0.900, 2.10, 4.50 and 10.0 mg/L
Measured Al: 5.88, 6.02, 7.72, 10.9, 16.7 and 25.7 ng/mL
Measured Zn: 6.31, 6.68, 9.19, 13.8, 24.0 and 44.3 ng/mL - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 75 mL glass vessels, fill volume: ca. 60 mL
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deionized water
- Culture medium different from test medium: no
- Intervals of water quality measurement:Oxygen concentration, temperature, hardness and pH values were measured once a week, in the fresh and old media, in of the control(s) and in the highest test substance concentration.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: light∶dark = 16 hours∶8 hours
- Light intensity: 1200 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :The numbers of living offspring were counted and the presence of aborted eggs or dead offspring were recorded. Mortality among the parent animals was recorded.
VEHICLE CONTROL PERFORMED: no vehicle - Reference substance (positive control):
- no
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.19 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- filtered test solution
- Basis for effect:
- reproduction
- Details on results:
- - Mortality of parent animals: 10% mortality was observed at the highest loading. No mortality occurred at lower test concentrations or in the control.
- No. of offspring produced per day per female: see Table under Any other information on results incl. tables - Reported statistics and error estimates:
- The estimation of the LOELR and NOELR was analyzed by the Bonferroni Test and Fisher's Exact Test. Statistical analysis of the data was accomplished with Toxcalc v5.0.26.
Reference
Number of live offspring:
Loading rate(mg/L) |
Cumulative No. of offspring after 21 days |
Parallel group |
|||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
||
Control |
Total |
107 |
102 |
98 |
127 |
94 |
108 |
101 |
134 |
93 |
103 |
0.190 |
Total |
95 |
101 |
100 |
98 |
101 |
102 |
103 |
121 |
120 |
84 |
0.430 |
Total |
67 |
75 |
86 |
80 |
80 |
92 |
70 |
81 |
70 |
72 |
0.900 |
Total |
67 |
73 |
92 |
75 |
36 |
71 |
84 |
70 |
88 |
70 |
2.10 |
Total |
96 |
70 |
65 |
93 |
70 |
68 |
67 |
109 |
89 |
74 |
4.50 |
Total |
44 |
80 |
M |
83 |
89 |
73 |
72 |
65 |
64 |
85 |
10.0 |
Total |
103 |
94 |
67 |
70 |
43 |
68 |
75 |
81 |
84 |
74 |
M: mortality
Description of key information
Nominal:
NOEC (21d) = 0.19 mg/L (Daphnia magna, OECD 211)
This value is taken into account for the PNEC derivation.
Measured (TWA):
Al: NOEC (21d) = 6.02 ng/mL (Daphnia magna, OECD 211)
Zn: NOEC (21d) = 6.88 ng/mL (Daphnia magna, OECD 211)
Key value for chemical safety assessment
Additional information
One study on the long-term toxicity of Zinc aluminium oxide to aquatic invertebrates is available. This key study was performed according to OECD Guideline 211, in a semi-static system, using Daphnia magna as test organism (2013).Nominal concentrations of 0.190, 0.430, 0.900, 2.10, 4.50 and 10.0 mg/L were prepared. The solutions were stirred for 72 hours and subsequently filtered. The daphnids were exposed to the filtered test solutions for 21 days. Mortality of parent animals (10%) was only observed at the highest loading. A NOEC of 0.19 mg/L based on reproduction was derived, corresponding to measured aluminium and zinc concentrations (time-weighted mean) of 6.02 ng/mL and 6.88 ng/mL, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.