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Diss Factsheets
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EC number: 262-975-0 | CAS number: 61788-44-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- Aim of this study was to evaluate the effect of test chemical on the mobility of aquatic invertevbrates.
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Common name: Water flea
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The effective concentration (EC50) value of test chemical in aquatic invertebrate (Daphnia magna) in a 48 hr study on the basis of mobility effect was observed to be 4.6 mg/L.
- Executive summary:
Aim of this study was to evaluate the effect of test chemical on the mobility of aquatic invertevbrates. Test conducted for 48 hrs. The effective concentration (EC50) value of test chemical in aquatic invertebrate (Daphnia magna) in a 48 hr study on the basis of mobility effect was observed to be 4.6 mg/L.
Reference
Description of key information
Aim of this study was to evaluate the effect of test chemical on the mobility of aquatic invertevbrate. Test conducted for 48 hrs. The effective concentration (EC50) value of test chemical in aquatic invertebrate (Daphnia magna) in a 48 hr study on the basis of mobility effect was observed to be 4.6 mg/L. The test chemical is highly insloluble in water the obtained EC50 value is much higher than the solubility of test chemical. Thus, by considering the solubility, test chemical cannot be toxic at its solubility limit.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4.6 mg/L
Additional information
Data available for test chemicals including structurally and functionally similar read across chemical, study has been reviewed to determine the short term toxicity of the test chemical on the growth and mobility of daphnia magna. The studies are as mentioned below:
Aim of this study was to evaluate the effect of test chemical on the mobility of aquatic invertevbrate. Test conducted for 48 hrs. The effective concentration (EC50) value of test chemical in aquatic invertebrate (Daphnia magna) in a 48 hr study on the basis of mobility effect was observed to be 4.6 mg/L. The test chemical is highly insloluble in water the obtained EC50 value is much higher than the solubility of test chemical. Thus, by considering the solubility, test chemical cannot be toxic at its solubility limit.
Above study was supported by the second data from peer reviewed journal. Short term toxicity of test chemical were studied was observing the effect of test chemical on the intoxication of freshwater aquatic invertebrate. 10 neonates <24h old Daphnia pulex in each test chamber not fed during the test were used in the study. Test conducted under the static system for 48 hrs. Based on the intoxication of Daphnia pulex after the exposure of 48 hrs, the EC50 was observed to 1.44 mg/l. The test chemical is highly insloluble in water the obtained EC50 value is much higher than the solubility of test chemical. Thus, by considering the solubility, test chemical cannot be toxic at its solubility limit.
Thus based on the above results, chemical consider to be non toxic at its maximum solubility limit
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