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EC number: 202-090-9 | CAS number: 91-68-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative Metabolism and Excretion of Resorcinol in Male and female F344 Rats
- Author:
- Kim YC, Matthews HB
- Year:
- 1 987
- Bibliographic source:
- Fundam Appl Toxicol 9 (3): 409-14 (l987)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Resorcinol
- Cas Number:
- Resorcinol
- Molecular formula:
- C6H6O2
- IUPAC Name:
- Resorcinol
- Reference substance name:
- 1,3-Benzenediol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- 1,3-Benzenediol
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- 1,3 benzenediol
- Details on test material:
- - Name of test material (as cited in study report): (14)C resorcinol
- Molecular formula (if other than submission substance): C6H6O2
- Molecular weight (if other than submission substance): 110.1 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Constituent 2
Constituent 3
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- A dose of 112 mg/kg of (14)C resorcinol was orally administered to 3 male and 3 female Fischer 344 rats. After one day, the animals were sacrificed, and major tissues and excretory products were analyzed to determine the fate of the resorcinol.
- Duration and frequency of treatment / exposure:
- 24 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
A single dose of 112 mg/kg of (14)C resorcinol
- No. of animals per sex per dose / concentration:
- 3
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Following oral administration, resorcinol was readily absorbed from the gastrointestinal tract
- Type:
- distribution
- Results:
- Resorcinol was seen to undergo enterohepatic circulation after administration
- Type:
- metabolism
- Results:
- Less than 50% of the parent compound was excreted in the urine, most was in the form of four metabolites. The major metabolite of resorcinol was a glucuronide conjugate (approximately 70%). One metabolite was identified as a sulfate conjugate (10-20%)
- Type:
- metabolism
- Results:
- one was identified as a diconjugate with glucuronide and sulfate (5-10%), and one, present in small quantities (less than 2%), was suggested to be a diglucuronide conjugate.
- Type:
- excretion
- Results:
- More than 90% of the total administered dose was recovered from the excreta in 24 hr. The primary route of excretion was in the urine. Only 1 to 2% of the dose was eliminated in the feces and less than 0.1% was eliminated as CO2.
- Type:
- excretion
- Results:
- Cannulation of the common bile duct followed by iv injection of 11.2 mg/kg resorcinol indicated that excretion in bile was rapid and underwent enterohepatic circulation to be excreted in the urine.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- glucuronide conjugate
sulfate conjugate
diconjugate with glucuronide and sulfate
diglucuronide conjugate
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
From the above information on absorption, distribution, metabolism and excretion of resorcinol; the bio-accumulation potential of the chemical appears to be low. - Executive summary:
In a 24 hour study with male and female Fisher 344 rats that were given a single oral dose of 112 mg/kg of (14)C resorcinol, more than 90% of the total administered dose was recovered from the excreta in 24 hrindicating little potential for bioaccumulation in animal tissues.Only trace amounts of the compound were found in any tissue and there was no evidence of specific organ accumulation
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