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EC number: 435-990-7 | CAS number: 371921-34-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February 15 to May 14, 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- 1981
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- 1992
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Yellow 981
- IUPAC Name:
- Yellow 981
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Analytical monitoring:
- yes
- Buffers:
- pH 4, 7, 9
Duration of testopen allclose all
- Duration:
- 2.4 h
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 2.4 h
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 2.4 h
- pH:
- 9
- Temp.:
- 50 °C
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Preliminary study:
- The preliminary study demonstrated a half-life of less than one day at pH 4 and 9 (degradation of over 50 % within 2.4 hours), therefore, the substance is considered hydrolytically unstable and no main test was required.
The solubility of test item in buffer solution pH 7.0 is too low to follow the degradation. - Test performance:
- Performance of the test
A preliminary test was performed at 50.2 °C at each of pH 4.0, pH 7.0 and pH 9.0. Aliquots of each test solution were analysed in time intervals using HPLC-UV/vis. Analysis was performed before incubation, after 2.4 hours and after 120 hours.
Preparation of the test solutions
pH 4.0
12.5 mg of test item were dissolved in 100 ml buffer solution (pH a.0) containing 2 % dimethylformamide as solubilizer. This mixture was ultrasonified for 3 minutes and submitted to a 0.2 µm filtration. To obtain a test solution of not more than half the water solubility, the solution was diluted 1:1 with the respective buffer. Two aliquots of this test solution of approximately 50 ml each were transferred into 50 ml Erlenmeyer flasks in order to perform a duplicate test.
pH 7.0
11.8 mg of test item were dissolved in 100 ml buffer solution (pH 7.0) containing 2 % dimethylformamide as solubilizer. This mixture was ultrasonified for 3 minutes and submitted to a 0.2 pm filtration. To obtain a test solution of not more than half the water solubility, the solution was diluted 1:1 with the respective buffer. Two aliquots of this test solution of approximately 50 ml each were transferred into 50 ml Erlenmeyer flasks in order to perform a duplicate test.
pH 9.0
10.3 mg of test item were dissolved in 100 ml buffer solution (pH 9.0) containing 2 % dimethylformamide as solubilizer. This mixture was ultrasonified for 3 minutes and submitted to a 0.2 pm filtration. To obtain a test solution of not more than half the water solubility, the solution was diluted 1:1 with the respective buffer. Two aliquots of this test solution of approximately 50 ml each were transferred into 50 ml Erlenmeyer flasks in order to perform a duplicate test. - Transformation products:
- not specified
Total recovery of test substance (in %)open allclose all
- % Recovery:
- < 50
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 2.4 h
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 2.4 h
- Remarks on result:
- other: poor solubility
- % Recovery:
- < 50
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 2.4 h
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- < 1 d
- Type:
- not specified
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- < 1 d
- Type:
- not specified
- pH:
- 7
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- solubility too low
- Details on results:
- The results of pH 4.0 and pH 9.0 showed a significant degradation of test item at 50 °C.
The degradation of test item was higher than 50 % after 2.4 hours. Accordingly, it can be concluded, that the estimated half-life time is shorter than one day under representative environmental conditions (25 °C). Therefore, test item was considered to be hydrolytically unstable, and no further testing was necessary at these pH values.
The solubility of test item in buffer solution pH 7.0 is too low to follow the degradation. A main test was not possible.
Applicant's summary and conclusion
- Conclusions:
- Half-life of the substance at 25 °C and pH 4 and 9 is less than one day, thus, it is hydrolytically unstable.
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