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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Referenceopen allclose all

Reference Type:
other: Authoritative data
Title:
Acute inhalation toxicity of test chemical in rats
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2018
Reference Type:
review article or handbook
Title:
Acute inhalation toxicity of test chemical
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials, 2012
Reference Type:
review article or handbook
Title:
Acute inhalation toxicity of test chemical
Author:
RTECS
Year:
2019
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database), 2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
To determine the Acute Inhalation toxicity of test chemical in rats.
GLP compliance:
not specified
Test type:
other: not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroacetyl chloride
EC Number:
200-926-7
EC Name:
Trichloroacetyl chloride
Cas Number:
76-02-8
Molecular formula:
C2Cl4O
IUPAC Name:
trichloroacetyl chloride
Test material form:
liquid
Details on test material:
IUPAC name: 2,2,2-trichloroacetyl chloride
Mol. formula: C2Cl4O
Molecular Weight:
181.833 gm/mol
Smiles:
C(C(=O)Cl)(Cl)(Cl)Cl
InChI: 1S/C2Cl4O/c3-1(7)2(4,5)6

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
not specified
Duration of exposure:
4 h
Remarks on duration:
not specified
Concentrations:
475mg/m3 (0.475 mg/l)
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
475 mg/m³ air (nominal)
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: No details available
Mortality:
50% mortality observed at a dose level of 475mg/m3.
Clinical signs:
other:
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 1 based on GHS criteria
Conclusions:
The LC50 for the test chemical was determined to be 475mg/m3 (0.475 mg/l) when administered to rats for 4 hours.
Executive summary:

Acute inhalation toxicity study was performed on rats to determine the toxic nature of test chemical. The test chemical was administered to rats via inhalation route for 4 hours. LC50 value of 475mg/m3 (0.475 mg/l) was observed indicating that the test chemical is highly toxic. As the LC50 value is < 0.5 mg/l, the test chemical can be classified as 'Category 1' for inhalation route according to CLP regulation.