Registration Dossier
Registration Dossier
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EC number: 619-753-7 | CAS number: 73611-02-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Remarks:
- other: 28 days dietary toxicity study
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27th April to 13th May 2002
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- OECD principles of Good Laboratory Practice for the testing of chemicals (C(97)186/Final)
- Limit test:
- yes
Test material
- Reference substance name:
- (1R, 4R, 5S) 4-hydroxy-6,6-dimethyl-3-Oxabicyclo[3.1.0]hexan-2-one
- EC Number:
- 619-753-7
- Cas Number:
- 73611-02-6
- Molecular formula:
- C7H10O3
- IUPAC Name:
- (1R, 4R, 5S) 4-hydroxy-6,6-dimethyl-3-Oxabicyclo[3.1.0]hexan-2-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- acetone
- Duration of treatment / exposure:
- Each test group received food specifically prepared for that group. The treatment was 7 days a week for 4 weeks. The high dose recovery group received normal rat food for two weeks following the 4 weeks of treatment period.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 500, 2000, 6000, 10000 ppm (m/f)
Basis:
nominal in diet
- No. of animals per sex per dose:
- 6
- Control animals:
- yes, plain diet
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 500 ppm
- Sex:
- male/female
- Basis for effect level:
- other: see 'Remark'
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
