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EC number: 627-083-1 | CAS number: 244235-47-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Version / remarks:
- July 1992
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 1-(2-Hydroxy-5-nonyl(branched)-phenyl)ethanone oxime
- EC Number:
- 627-083-1
- Cas Number:
- 244235-47-0
- IUPAC Name:
- 1-(2-Hydroxy-5-nonyl(branched)-phenyl)ethanone oxime
- Test material form:
- liquid: viscous
- Details on test material:
- - Physical state: amber-coloured, vicous liquid
- Analytical purity: 89%
- Impurities (identity and concentrations): 11% Nonylphenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Tierzucht Schönwalde GmbH
- Weight at study initiation: 146-173 g
- Fasting period before study: 18 hours
- Housing: 2-3 animals per cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 9 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +- 3
- Humidity (%): 55 +- 15
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- The test article was administered orally by gavage to rats fasted for approximately 18 hours prior to dosing. After dosing diet was withheld for a further 3 hours. Dosing took place between 9.30 and 10.00 a.m.
The study was initiated with a sighting study:
One female rat SAT 960 824 was given in a 2000 mg/kg b.wt. dose. Slight signs of toxicity were observed in this rat.
On the basis of the results from the sighting study it was decided to carry out the main study with one group consisting of five male and five female rats given a dose of 2000 mg/kg b.wt.
The dose volume administered was 10 ml/kg b.wt. both in sighting and main study. - Doses:
- 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Each rat was observed 1, 3 and 6 hours after administration and thereafter daily for aperiod
of 14 consecutive days. Body weight was recorded on days 0, 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross necropsy - Statistics:
- N/A
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: Males After 1 hour all animals showed diarrhoe, decreased motor activity and piloerection. After 3 and 6 hours decreased motor activity and piloerection were seen in all animals. On day 1 only piloerection was observed. From day 2 until the end of observa
- Gross pathology:
- The gross necropsy of male and female rats revealed no pathological abnormalities.
- Other findings:
- none stated
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a study according to OECD Test guideline 420 (acute oral toxicity) under GLP, the rat LD50 of the test substance was determined to be > 2000mg/kg bodyweight and is therefore considered to be practically nontoxic.
- Executive summary:
The acute oral toxicity of the test substance was evaluated in a study according to OECD Test Guideline 420 under GLP. A limit test with the test substance dose of 2000 mg/kg bodyweight was performed. The substance was applied with the vehicle sesame oil by oral gavage to five Wistar rats of both sexes, which were observed for 14 days post application. No mortality occured. Body weights gain was not impaired, while no pathological abnormalities were found. Clinical signs like diarrhoea, pilorection or decreased motor acitivity was observed maximally until day 2. Based on these results, the rat oral acute toxicity LD50 of the test substance was > 2000mg/kg bodyweight. Therefore, the test substance is considered practically non-toxic.
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