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Diss Factsheets
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EC number: 212-091-6 | CAS number: 762-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Short-term toxicity to fish (Danio rerio) of the substance was determined as LC0 = 99.8 mg/L and LC100 = 438.0 mg/L. The geometric mean of both LC values gabe an EC 50 = 209.1 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 209.1 mg/L
Additional information
Rational for read across
REACH regulation (Corrigendum) EC 1907/2006 on page L 136/120: “Substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or ‘category’ of substances. Application of the group concept requires that physicochemical properties, human health effects and environmental effects or environmental fate may be predicted from data for reference substance(s) within the group by interpolation to other substances in the group (read-across approach).”
Further, ECHA guidance document “Guidance on information requirements and chemical safety assessment – Chapter R.6: QSARs and grouping of chemicals (May, 2008)” provides information on the use of read-across (page 78) as follows: “In the read-across technique, endpoint information for one chemical is used to predict the same endpoint for another chemical, which is considered to be similar in some way (usually on the basis of structural similarity). In principle, read-across can be applied to characterise physico-chemical properties, environmental fate, human health effects and ecotoxicity.”
Triethyl posphite (CAS 122 -52 -1) and diethyl phospite (762 -04 -9) are very similar in their chemical structure. However, there is a more relevant rational for the use of studies conducted with triethyl phosphite: In contact with water triethyl phosphite quickly hydrolyses with diethyl phosphite being the hydrolysis product. This product is expected to be stable for a certain time period which should be the period of an acute toxicity study. Thus, when conducting a study with triphenyl phosphite it should be the effects of diethyl phosphite that are detected instead.The other hydrolysis product phosphate can be expected not to cause any toxicity since it is an ubiquitious and inorganic compound.
Concluding, it is highly justified to use studies with triethyl phosphite to predict effects with diethyl phosphite.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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