3,7,11,15-tetramethylhexadec-1-en-3-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Deviations from current standart test protocols, e.g. 8 h exposure, no analytical verification of test substance concentration, heating of test material (100° C)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1970

Report date:

1970

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Inhalation hazard test, no guideline available at that time.

GLP compliance:

no

Test type:

other: Inhalation hazard test

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Automatically generated during migration to IUCLID 6, no data available

IUPAC Name:

Automatically generated during migration to IUCLID 6, no data available

Details on test material:

- Name of test material (as cited in study report): Isophytol G
- Physical state: fluid
- Analytical purity: ca. 90 %
- Impurities (identity and concentrations): not reported

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: 200 l/h directed through a 5 cm layer of the test substance at 100°C and 20°C, respectively

Analytical verification of test atmosphere concentrations:

no

Remarks:

Estimation by decrease in test substance weight during experiment

Duration of exposure:

8 h

Concentrations:

1.11 mg/l (91.52 ppm) at 100°C; concentration at 20 °C not detectable, no decrease in test substance weight

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: no data
- Frequency of observations and weighing: weighing before exposure and before necropsy; frequency of observations not reported
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, cage side observations

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LC0

Effect level:

>= 1.11 mg/L air

Exp. duration:

8 h

Remarks on result:

other: Preparation of vapour by heating of test substance to 100°C

Effect levels 2

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 1.1 mg/L air

Exp. duration:

8 h

Remarks on result:

other: Preparation of vapour by heating of test substance to 100°C

Mortality:

No mortality occured (vapour preparation at 100°C, test at 20°C was not assessable because vapour concentration could not be determined).

Gross pathology:

No findings (vapour preparation at 100°C and 20°C).

Other findings:

- Other observations: Slight attempts to escape (vapour preparation at 100°C); no findings after vapour preparation at 20°C

Any other information on results incl. tables

No mortality occured after 8 hours inhalation of an atmosphere containing test substance vapous prepared at 100°C. Necropsies showed no findings.

The exposure to an atmosphere containing test substance vapours prepared at 20°C could not be assessed because no decrease in test substance weight was determined.