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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No OECD Guideline or GLP defined; insufficient data documentation, no standard method.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960
Report date:
1960

Materials and methods

Principles of method if other than guideline:
other: single intraperitoneal application
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chlorophenyl isocyanate
EC Number:
220-822-5
EC Name:
3-chlorophenyl isocyanate
Cas Number:
2909-38-8
Molecular formula:
C7H4ClNO
IUPAC Name:
1-chloro-3-isocyanatobenzene
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
0.01, 0.025, 0.0375, 0.05, 0.1 ccm/kg bw.
No. of animals per sex per dose:
0.01 ccm/kg bw = 3animals;
0.025 ccm/kg bw = 3 animals;
0.0375 ccm/kg bw = 5 animals;
0.05 ccm/kg bw = 5 animals;
0.1 ccm/kg bw = 3 animals.
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
3.038 other: ccm/kg bw
Remarks on result:
other: No characteristical signs of toxicity could be observed.

Any other information on results incl. tables

Results:

0.01 ccm/kg; 0.1 % in oil; 0/0/3*;

0.025 ccm/kg; 0.25 % in oil; 0/3/3;

0.0375 ccm/kg; 0.375 % in oil; 2/5/5;

0.05 ccm/kg; 0.5 % in oil; 4/5/5;

0.1 ccm/kg; 1.0 % in oil; 3/3/3.

Applicant's summary and conclusion

Executive summary:

In an acute intrapperitoneal toxicity study in male rats the test substance in oil was injected to the animals using following doses: 0.01, 0.025, 0.0375, 0.05, 0.1 ccm/kg bw.

The LD 50 was found to be 0.075 ccm/kg bw. No characteristical signs of toxicity could be observed.