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Diss Factsheets
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EC number: 605-539-0 | CAS number: 169115-74-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed isopropanolamine
- Author:
- Cosmetic Ingredient Review
- Year:
- 1 987
- Bibliographic source:
- Journal of the Americal College of Toxicology, Volume 6, No. 1, 53-76, 1987
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Draize repeat insult patch test for skin sensitization and photosensitization
Test material
- Reference substance name:
- 1-aminopropan-2-ol
- EC Number:
- 201-162-7
- EC Name:
- 1-aminopropan-2-ol
- Cas Number:
- 78-96-6
- IUPAC Name:
- 1-aminopropan-2-ol
- Reference substance name:
- 1-amino-2-propanol
- IUPAC Name:
- 1-amino-2-propanol
Constituent 1
Constituent 2
Method
- Type of population:
- general
- Subjects:
- 150 male and female volunteers (no further information)
- Route of administration:
- dermal
- Details on study design:
- 0.2 ml volume of an aqueous solution containing 2% isopropanolamine was applied to patches, and the patches were applied occlusively to the lower backs of 150 volunteers for 48 to 72 hours three times a week for 3 weeks. Sites were scored at patch removal. A challenge patch was applied 2 weeks later to a naive site. It was scored at 48 and 96 h on a scale of 0-4.
Results and discussion
- Results of examinations:
- not sensitizing
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 0
- Number of subjects with negative reactions: 150
Applicant's summary and conclusion
- Executive summary:
In a modified Draize repeat insult patch test a 2 % aqueous solution of isopropanolamine was tested for skin sensitizing effects in 150 male and female human volunteers. Three times a week for three weeks 0.2 ml of the solution on a patch were applied occlusively for 48 to 72 hours on the lower back of each volunteer. A challenge patch was applied 2 weeks later to a naive site. Effects to the skin were scored at 48 and 96 h. Isopropanolamine did not induce allergic contact dermatitis.
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