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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 December 2010 - 07 January 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with recognised study guidelines and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Details on test material:
- Name: Reactive Blue F08-0170
Constituent 1
Results and discussion
Water solubilityopen allclose all
- Water solubility:
- > 145.02 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: +/- 9.70 g/L (95% confidence interval) based on Component 1. pH values are tabulised below.
- Water solubility:
- > 139.6 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: +/-2.13 g/L (95% confidence interval) based on Component 2. pH values are tabulised below.
- Water solubility:
- > 129.92 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: +/-10.54 g/L (95% confidence interval) based on Component 3. pH values are tabulised below.
- Water solubility:
- > 122.35 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: +/-9.24 g/L (95% confidence interval) based on Component 4. pH values are tabulised below.
- Details on results:
- Water Solubility
Measured concentrations of Reactive Blue F08-0170 are summarised in Table 3-6 below. The repeatability of the determination was <15%, and thus within the range required by the guidelines.
The study was supplemented with a sample preparation trial in order to justify the saturation of the water solubility samples.
4.00 g Reactive Blue F08-0170 was weighed into a stoppered Erlenmeyer flasks. After the addition of 20 ml water, the flasks were agitated at 30°C. Passing 1 day the flasks were removed and re-equilibrated at 20°C for 24 hours. The samples were centrifuged and filtered (0.45 µm membrane filter) and diluted with Acetonitrile : Water = 1 : 9 mixture. The concentration of the sample was determined by HPLC.
The result were higher than the concentrations measured during the main test.
Any other information on results incl. tables
Measured concentrations of Reactive Blue F08-0170are summarised in Table 3-6 below. The repeatability of the determination was <15%, and thus within the range required by the guidelines.
Table 3. Results of the determination of Reactive Blue F08-0170 (Component 1) concentrations
Measured concentration after 24 hours (g/l) |
Measured concentration after 48 hours (g/l) |
Measured concentration after 72 hours (g/l) |
Solubility ofthe test item (g/l) |
142.6 |
149.1 |
142.8 |
145.02 ± 9.70 |
149.0 |
145.1 |
141.2 |
|
143.2 |
152.7 |
139.5 |
|
Mean: 144.9 |
Mean: 149.0 |
Mean: 141.2 |
Table 4. Results of the determination of Reactive Blue F08-0170 (Component 2) concentrations
Measured concentration after 24 hours (µg/ml) |
Measured concentration after 48 hours (µg/ml) |
Measured concentration after 72 hours (µg/ml) |
Solubility ofthe test item (µg/ml) |
138.3 |
140.1 |
138.0 |
139.60 ± 2.13 |
144.7 |
137.6 |
138.0 |
|
138.0 |
141.8 |
139.9 |
|
Mean: 140.3 |
Mean: 139.8 |
Mean: 138.7 |
Table 5. Results of the determination of Reactive Blue F08-0170 (Component 3) concentrations
Measured concentration after 24 hours (µg/ml) |
Measured concentration after 48 hours (µg/ml) |
Measured concentration after 72 hours (µg/ml) |
Solubility ofthe test item (µg/ml) |
130.9 |
124.5 |
130.3 |
129.92 ± 10.54 |
134.6 |
123.0 |
132.8 |
|
129.7 |
127.7 |
135.7 |
|
Mean: 131.7 |
Mean: 125.1 |
Mean: 133.0 |
Table 6. Results of the determination of Reactive Blue F08-0170 (Component 4) concentrations
Measured concentration after 24 hours (µg/ml) |
Measured concentration after 48 hours (µg/ml) |
Measured concentration after 72 hours (µg/ml) |
Solubility ofthe test item (µg/ml) |
121.5 |
117.6 |
123.2 |
122.35 ± 9.24 |
125.9 |
117.1 |
126.1 |
|
120.8 |
120.7 |
128.3 |
|
Mean: 122.7 |
Mean: 118.5 |
Mean: 125.9 |
Table 7. Measured pH values
Measured pH values after 24 hours |
Measured pH values after 48 hours |
Measured pH values after 72 hours |
5.28 |
5.22 |
5.19 |
5.25 |
5.21 |
5.17 |
5.25 |
5.18 |
5.15 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of Reactive Blue F08-0170 was determined to be:
- higher than 145.02 +/- 9.70 g/L (95% confidence interval) based on Component 1,
- higher than 139.60 +/- 2.13 g/L (95% confidence interval) based on Component 2,
- higher than 129.92 +/- 10.54 g/L (95% confidence interval) based on Component 3,
- higher than 122.35 +/- 9.24 g/L (95% confidence interval) based on Component 4
at 20°C ± 1°C using the shake-flask method for the performance of the main test. - Executive summary:
In conclusion, the water solubility of Reactive Blue F08-0170 was determined to be:
- higher than 145.02 ± 9.70 g/L (95% confidence interval) based on Component 1,
- higher than 139.60 ± 2.13 g/L (95% confidence interval) based on Component 2,
- higher than 129.92 ± 10.54 g/L (95% confidence interval) based on Component 3,
- higher than 122.35 ± 9.24 g/L (95% confidence interval) based on Component 4
at 20°C ± 1°C using the shake-flask method for the performance of the main test.The various components of the substance are considered to be very soluble in water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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