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EC number: 226-364-2 | CAS number: 5372-81-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed GLP and OECD guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dimethyl 2-aminoterephthalate
- EC Number:
- 226-364-2
- EC Name:
- Dimethyl 2-aminoterephthalate
- Cas Number:
- 5372-81-6
- Molecular formula:
- C10H11NO4
- IUPAC Name:
- 1,4-dimethyl 2-aminobenzene-1,4-dicarboxylate
- Reference substance name:
- dimethyl-2-aminoterephthalate
- IUPAC Name:
- dimethyl-2-aminoterephthalate
- Details on test material:
- - Name of test material (as cited in study report): Aminoterephthalsäuredimethylester
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Chemical pharmaceutical factory Dr. K. Thomae
- Age at study initiation: about 3 - 5 months
- Weight at study initiation: 2.1-2.2 kg
- Housing: in fully air-conditioned rooms, separate cages
- Diet (e.g. ad libitum): Altromin 2123 maintenance diet - rabbits, ad libitum
- Water (e.g. ad libitum): from automatic water dispensers, ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3
- Humidity (%): 50 ±20
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: Polyethylene glycol 400
- Controls:
- not required
- Amount / concentration applied:
- Each animal was treated with 0.5 g test item mixed with 0.3 ml polyethylene glycol 400
- Duration of treatment / exposure:
- The exposure period was 4 hours. After the exposure period all remnants of the test substance were carefully removed from the skin with warm tap water.
- Observation period:
- Examinations of the skin took place after 30 - 60 min as well as 24, 48, 72 hours after removal of the patches.
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: # 176, 177, 178 each
- Time point:
- other: mean of 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no signs of irritation (erythema) at any time
- Irritation parameter:
- edema score
- Basis:
- other: # 176, 177, 178 each
- Time point:
- other: mean of 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no signs of irritation (edema) at any time
- Irritant / corrosive response data:
- Throughout the whole study no irritations were observed at the treated skin of the animals.
- Other effects:
- no other effects reported
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based on the findings in this test the test substance is neither skin irritating nor skin corrosive.
- Executive summary:
Aminoterephthalsäuredimethylester was tested for skin irritating properties according to OECD 404. Following this protocol 500 mg test substance mixed with 0.3 ml polyethylene glycol 400 were applied to the shaved skin of 3 New Zealands White rabbits. After 4 h exposure time the semioccolusive patch was removed. Residual substance was removed with warm tap water. Animals were examined for signs of skin irritation/corrosion at 30 - 60 min, 24, 48 and 72 hours after removal of the patches. Mean scores (mean of 24, 48, 72 h) were calculated for oedema and erythema for each rabbit.
Based on the findings in this test the test substance is neither skin irritating nor skin corrosive.
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