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EC number: 211-687-3 | CAS number: 686-31-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2a Guideline study without detailed documentations (no certificat of analysis for example)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.4l.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- tert-pentyl 2-ethylperoxyhexanoate
- EC Number:
- 211-687-3
- EC Name:
- tert-pentyl 2-ethylperoxyhexanoate
- Cas Number:
- 686-31-7
- Molecular formula:
- C13H26O3
- IUPAC Name:
- 2-methylbutan-2-yl 2-ethylhexaneperoxoate
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): tert-amyl peroxyoctoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: purchased from H.A.R.E. - Rabbits for Research, Hewitt, N.J. for use in this study.
- Age at study initiation: no data
- Weight at study initiation: 2-4 kg
- Housing :individually in wire mesh bottom cages in an environment-controlled room.
- Diet and water : ad libitum
- Acclimation period: quarantined for a minimum of 5 day
ENVIRONMENTAL CONDITIONS
All housing and care conformed to the sta'ndards established in "Guide for the Care and use of Laboratory Animals" DHEW publication
No. (NIH) 78-23.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved or abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 or 72 hours
- Number of animals:
- 6
- Details on study design:
- Shortly before dosing, the dorsal surface of each rabbit was clipped free of fur with electric clippers.
During this procedure, care was taken to avoid accidential abrasion to the skin.
Just prior to test article application, the test site on the right dorsal side was abraded with the tip of a 22 gauge hypodermic needle. The abrasions were 4 incisions made in cross hatch which penetrated the stratum corneum but did not disturb the derma and/or produce bleeding.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: erythema and edema scores
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Max. score:
- 0
- Remarks on result:
- other: shaved skin
Any other information on results incl. tables
Scores:
Exposure time (h) | Skin | Rabbit 1 | Rabbit 2 | Rabbit 3 | Rabbit 4 | Rabbit 5 | Rabbit 6 | |
Erythema and eschar formation | 24 | intact | 2 | 2 | 2 | 1 | 1 | 1 |
72 | intact | 0 | 0 | 0 | 0 | 0 | 0 | |
24 | abraded | 2 | 2 | 2 | 1 | 1 | 1 | |
72 | abraded | 0 | 0 | 0 | 0 | 0 | 0 | |
Edema formation | 24 | intact | 0 | 1 | 1 | 0 | 0 | 1 |
72 | intact | 0 | 0 | 0 | 0 | 0 | 0 | |
24 | abraded | 0 | 1 | 1 | 0 | 0 | 1 | |
72 | abraded | 0 | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- After a 24-hour exposure period under occlusive conditions, tert-amyl peroctoacte is not irritating for rabbit skin.
- Executive summary:
The acute dermal irritation of tert-amylperoctoate was evaluated in rabbits according to 16 CFR 1500.4l. guideline and in compliance with GLP. The test item was applied undiluted to the skin of 3 New Zealand White rabbits (shave skin or abraded skin) and held in contact for 24 hours by means of an occlusive dressing.
Mean scores over 24, and 72 hours for each animal were for erythema and eschar foramation, and for edema.
On shaved skin, no irritation was observed (all scores were 0). On abraded skin, slight to moderate signs of irritation were observed but only at 24 hours, not at 72 hours.
Under the experimental conditions, after a 24-hour exposure period under occlusive conditions, tert-amyl peroctoacte is not irritating for rabbit skin.
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