Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-152-2 | CAS number: 78-87-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines. Methods presented in separate (1962) publication.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- A Range-finding toxicity data: List VII
- Author:
- Smyth et al
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal. 1969; 30; 470-476
- Reference Type:
- publication
- Title:
- No information
- Author:
- Smyth et al
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal. 1962; 23; 95-107
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- One-day cuff method of Draize and associates.
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- Name of test material (as cited in publication): 1,2-Dichloropropane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Trunk
- Type of wrap if used: Impervious plastic film - Duration of exposure:
- 24 hours
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no - Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 10 100 mg/kg bw
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, the dermal LD50 for PDC in male rabbits was 8.75 ml/kg bw (10100 mg/kg bw).
- Executive summary:
PDC was applied to clipped skin of male albino rabbits (2.5 - 3.5 kg) under occlusion for 24 hr. The animals were immobilised during expoure, then returned to their cages and observed for 14 days.
An LD50 of 8.75 ml/kg bw was reported. This is equivalent to 10,100 mg/kg bw, based on a density of 1.155 g/ml [Source: MacKay et al (1993) Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals, Vol III, p479]
Under the conditions of the study, the dermal LD50 for PDC in male rabbits was 8.75 ml/kg bw (10100 mg/kg bw); which according to EU
criteria is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
