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Diss Factsheets
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EC number: 209-264-3 | CAS number: 563-80-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 hour exposure followed by a 14-day observation period
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted according to acceptable scientific standards and reviewed by Quality Assurance. Additionally, the results of this study are valid for classification in that the conditions of exposure are more stringent than in current guidelines. Conduct of the study according to all aspects of GLP could not be confirmed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- no
- Principles of method if other than guideline:
- Five male guinea pigs (age not specified) were administered a single dose of 0.5 mL of the test substance to the depilated abdomen. An occlusive wrap was used to hold the substance against the skin for 24 hours. The skin was observed daily for irritant responses. The skin was observed for signs of erythema, edema, necrosis, eschar, scarring, staining, and erosion. Effects were graded as very slight, slight, moderate or strong. Body weights were recorded on a weekly basis. No gross pathology was performed at study termination.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-methyl-2-butanone
- IUPAC Name:
- 3-methyl-2-butanone
- Reference substance name:
- 3-methylbutanone
- EC Number:
- 209-264-3
- EC Name:
- 3-methylbutanone
- Cas Number:
- 563-80-4
- Molecular formula:
- C5H10O
- IUPAC Name:
- 3-methylbutan-2-one
- Reference substance name:
- methylbutanone; methyl isopropyl ketone; MIPK
- IUPAC Name:
- methylbutanone; methyl isopropyl ketone; MIPK
- Details on test material:
- -Test substance: Methyl isopropyl ketone
-Date of manufacture: October 1987
-Source: Tennessee Eastman Company
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Details on test animals or test system and environmental conditions:
- Test animals:
-Sex: male
-Strain: Crl:(HA)BR Hartley
-Body weight (at study initiation): 502-582 g
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved, then depilated with a chemical depilatory
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 14 days
- Number of animals:
- 5 animals (male)
- Details on study design:
- Five guinea pigs (male) were administered a single dose of 0.5 mL of the test substance to the depilated abdomen. An occlusive wrap was used to hold the substance against the skin for 24 hours. After removal of the wrap, the skin was rinsed with water. The site of exposure was observed daily for irritant responses. Body weights were recorded on a weekly basis. No gross pathology was performed at study termination.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: overall irritation – description
- Basis:
- animal: 1, 2, 3, 4, 5
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: Slight erythema was observed in all animals. All animals appeared clinically normal by 72 hours after termination of exposure to the test substance.
- Irritant / corrosive response data:
- Signs of irritation were restricted to slight erythema at the site of application. No numerical scores were provided in the study. Irritation was rated on a descriptive scale from very slight to strong.
- Other effects:
- All animals gained weight (99-128 g) over the course of the study. Additionally, all animals gained weight during both Week 1 and Week 2 of the study.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Methyl isopropyl ketone was not acutely toxic, irritating, or corrosive after a 24 hour dermal exposure to Hartley guinea pigs under the occlusive conditions used in this study. There was no evidence of edema or eschar formation and erythema was, at most, slight at the site of application. All animals appeared clinically normal by 72 hours after termination of exposure and all animals gained weight normally over the course of the study.
Based on slight erythema that cleared by 72 hours post-exposure, methyl isopropyl ketone is not classifiable for Skin Irritation/Corrosion according to GHS. - Executive summary:
In a skin irritation/corrosion study, 5 Hartley guinea pigs were exposed to 0.5 mL of undiluted methyl isopropyl ketone under occlusion for 24 hours. After 24 hours, the test site was rinsed with running water. The site of application was then examined daily for irritant responses for 14 days. Signs of irritation were limited to slight erythema, with all animals appearing clinically normal at 72 hours after termination of exposure. Based on the results of this study, methyl isopropyl ketone presents a low toxicity hazard and is not considered an irritant or corrosive.
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