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EC number: 617-976-4 | CAS number: 871544-06-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6 January 2005 - 3 February 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
- Reference substance name:
- lithium(1+) [2-methoxy-4-(trifluoromethyl)pyridin-3-yl]sulfanide
- EC Number:
- 617-976-4
- Cas Number:
- 871544-06-8
- Molecular formula:
- C7H5NOF3S.Li
- IUPAC Name:
- lithium(1+) [2-methoxy-4-(trifluoromethyl)pyridin-3-yl]sulfanide
- Details on test material:
- 3-Pyridinethiol, 2-methoxy-4-(trifluoromethyl)-lithium salt
Appearance: dark brown aqueous solution
Storage: room temperature
pH: 11 - 12 (by wetted pH paper)
Solubility: soluble in water, methanol, ethanol, and acetone. Mineral oil: 3-Pyridinethiol, 2-methoxy-4-(trifluoromethyl)-lithium salt soluble, aqueous solution not soluble.
Stability: test substance was expected to be stable for the duration of testing
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Raleigh, NC
- Age at study initiation: 9 - 12 weeks
- Weight at study initiation: 120 - 140 g
- Fasting period before study: overnight
- Housing: The animals were singly housed in suspended stainless steel caging with mesh floors. Litter paper was placed beneath the cage and was changed at least three times per week.
- Diet (e.g. ad libitum): Purina Certified Rodent Diet (PMI #5002)
- Water (e.g. ad libitum): Filtered tap water was supplied ad libitum by an automatic water dispensing system.
Contaminants: There were no known contaminants reasonably expected to be found in the food or water at levels which would have interfered with the results of this study. Analysis ofthe water is conducted at least once a year and the records are kept on file at Product Safety Laboratories. The most recent analysis was conducted in December 2004. Purina Certified Rodent Diet, PMI #5002, Lot Numbers: SEP 23 04 2B and NOV 23 04 3A, were analyzed in October and December 2004, respectively.
- Acclimation period: 8 - 30 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 24°C
- Humidity (%): 30 - 66% relative
- Photoperiod (hrs dark / hrs light): 12-hour light/dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- -Dose Calculations
Individual doses were calculated based on the initial body weights, taking into account the specific gravity (determined by PSL) of the test substance.
-Dosing
The test substance was administered using a stainless steel ball-tipped gavage needle attached to an appropriate syringe. Following administration, each animal was returned to its designated cage. Feed was replaced immediately after dosing.
Individual animals were dosed as follows:
Dosing Animal Dose Level Short Long
Sequence No. (mg/kg) Term Term
1 9996 175 S S
2 110 550 S S
3 122 1,750 S S
4 132 5,000 D D
5 194 1,750 D D
6 327 5,000 S S
7 413 1,750 S S
8 421 5,000 D D
S = Survival
D = Death
The test substance was administered in sequence to the animals as described above. The decision to proceed with the next animal was based on the survival of the previous animal in the short-term period following dosing. Dose progressions and stopping criteria were determined using a statistical program. - Doses:
- 175 mg/kg, 550 mg/kg, 1,750 mg/kg and 5,000 mg/kg
- No. of animals per sex per dose:
- 175 mg/kg (1 animal); 550 mg/kg (1 animal); 1750 mg/kg (3 animals); 5000 mg/kg (3 animals). All animals were female.
- Control animals:
- not specified
- Details on study design:
- -Body Weights
Individual body weights of the animals were recorded prior to test substance administration (initial) and again on Days 7 and 14 (termination).
-Cage-Side Observations
The animals were observed for mortality, signs of gross toxicity, and behavioural changes during the first several hours post-dosing and at least once daily thereafter for up to 14 days after dosing. Observations included gross evaluation of skin and fur, eyes and mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity and behaviour pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhoea, and coma.
-Necropsy
Surviving rats were euthanized via CO2 inhalation at the end of the 14-day observation period. Gross necropsies were performed on all decedents and euthanized animals. The external surface of the body and all orifices, tissues, and organs of the thoracic and abdominal cavities were examined. - Statistics:
- The Acute Oral Toxicity (Guideline 425) Statistical Program (Weststat, version 1.0, May 2001) was used for all data analyses including: dose progression selections, stopping criteria determinations and/or LD50 and confidence limit calculations.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 129 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 750 - < 5 000
- Remarks on result:
- other: 95% confidence interval of 1,750 mg/kg (lower) to 5000 mg/kg (upper)
- Mortality:
- There were no mortalities at dose levels 175 mg/kg (1 animal), 550 mg/kg (1 animal) and 1,750 mg/kg (3 animals).
At the 5,000 mg/kg dose level, all three animals died within 1 day of test substance administration. - Clinical signs:
- other: At dose levels 175 mg/kg (1 animal), 550 mg/kg (1 animal) and 1,750 mg/kg (3 animals) all animals appeared active and healthy during the study. There were no signs of gross toxicity, adverse clinical signs, or abnormal behaviour; apart from 1 animal at th
- Gross pathology:
- At dose levels 175 mg/kg, 550 mg/kg and 1,750 mg/kg no gross abnormalities were noted for any of the animals when necropsied at the conclusion of the 14-day observation period.
At the 5,000 mg/kg dose level, gross necropsy of the decedents revealed discoloration of the intestines (red).
Any other information on results incl. tables
Individual Body Weights, Doses and Mortality:
Animal No. |
Sex |
Dose level (mg/kg) |
Body weight (g) |
Dose |
Mortality |
||
Initial |
Day 7 |
Day 14 |
mL* |
Day |
|||
9996 |
F |
175 |
137 |
142 |
160 |
0.022 |
E |
110 |
F |
550 |
120 |
131 |
157 |
0.060 |
E |
122 |
F |
1,750 |
122 |
150 |
170 |
0.20 |
E |
194 |
F |
126 |
134 |
151 |
0.20 |
E |
|
413 |
F |
140 |
151 |
167 |
0.23 |
E |
|
132 |
F |
5,000 |
132 |
- |
- |
0.61 |
0 |
327 |
F |
130 |
- |
- |
0.60 |
0 |
|
421 |
F |
123 |
- |
- |
0.56 |
1 |
E - Euthanized via CO2 inhalation after weighing on Day 14
*The test substance was administered as received. Specific Gravity 1.090 g/mL.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the acute oral LD50 of the test substance was estimated to be 3,129 mg/kg of body weight in female rats with approximate 95% confidence intervals of 1,750 mg/kg (lower) to 5,000 mg/kg (upper).
- Executive summary:
Under the conditions of this study, the acute oral LD50 of the test substance was estimated to be 3,129 mg/kg of body weight in female rats with approximate 95% confidence intervals of 1,750 mg/kg (lower) to 5,000 mg/kg (upper). The study was conducted in accordance with U.S. EPA Health Effects Test Guidelines, OPPTS 870.1100 (2002).
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