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Diss Factsheets
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EC number: 231-388-1 | CAS number: 7526-26-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.001 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.013 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 0.2 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.039 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.004 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.007 mg/kg soil dw
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 0.128 mg/kg food
- Assessment factor:
- 3 000
Additional information
Derivation of PNECs
The Predicted No Effect Concentrations (PNECs) for the different environmental compartments are calculated either by application of an assessment factor (AF) (PNECfreshwater, PNECmarine water, PNECintermittent release, PNECstp, PNECsoil and PNECoral) or by utilisation of the equilibrium partitioning method (EPM) (PNECsediment-freshwater and PNECsediment-marine water). The PNECair is not considered as relevant based on the chemical structure and intrinsic properties of Diphenyl methylphosphonate. Exposures to the terrestrial compartment and sewage treatment plants (STP) are not intended since the substance is not placed onto the market as a monomer and will be used in the production of polymeric products only resulting in a chemical bonding. Thus, for derivation of the PNECsoil, an authentic QSAR result is taken into account and the PNECstp is derived based on available biodegradation data. Also secondary poisoning of mammals and/or birds is not to be expected, however, the PNECoral can be derived by a reliable QSAR prediction for Coturnix japonica (Japanese quail). All procedure applied are described in detail in the ECHA REACH Guidance (May 2008), Chapter R.10 (“Characterisation of dose [concentration]-response for environment”).
Classification and labelling for the environmental compartment
Experimental results of Diphenyl methylphosphonate are available for evaluating toxicity towards aquatic vertebrate and invertebrate species. Evaluation of terrestrial toxicity, metabolism, and environmental behaviour characteristics (i.e. biodegradation) are covered by authentic QSAR predictions using the OECD QSAR Toolbox and EPIWIN software by US-EPA. No long-term investigation results are available (and not triggered), thus reliable acute toxicity data for three trophic aquatic levels (i.e. fish, daphnids and algae) are the basis for the Chemical Safety Assessment (CSA) of the test substance.
Diphenyl methylphosphonate was found to be not readily biodegradable under test conditions according to OECD Guideline 301D by attaining 3 % degradation in 28 days (Clarke, 2012). This is supported by the outcome of reliable QSAR predictions with EPIWIN (Chemservice S.A., 2011) and OECD QSAR Toolbox (Chemservice S.A., 2012).
The most critical experimental result was found in the acute toxicity test conducted with Daphnia magna (OECD Guideline 202; Harris, 2013), revealing an EC50(48h) of 1.3 mg/L. Toxicity effects were also reported by the experimental results for fish (LC50(96h): 20 mg/L; OECD Guideline 203; Harris, 2013) and algae (ErC50(72h): 15 mg/L; OECD Guideline 201; Vryenhoef, 2013). All studies were conducted under certificated GLP compliance and all validity criteria were fulfilled.
Taken into account all available data, classification and labelling criteria in accordance to Regulation (EC) No 1272/2008 with respect to environmental hazards are fulfilled.
Conclusion on classification
Diphenyl methylphosphonate (DPP) has to be classified and labelled in accordance to Regulation (EC) No 1272/2008 of the European Parliament and of the Council. The classification is “Aquatic Chronic 2” with Hazard Statement 411 (H411; Toxic to aquatic life with long lasting effects) and Precautionary statements P273 (Avoid release to the environment), P391 (Collect spillage) and P501 (Dispose of contents/container in accordance with local/regional/national/international regulations). For labelling, the corresponding is GHS09 (environment) and no signal word has to be used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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