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EC number: 401-540-3 | CAS number: 84632-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Explosiveness
Administrative data
Link to relevant study record(s)
- Endpoint:
- explosive properties of explosives
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.14 (Explosive properties)
- GLP compliance:
- yes (incl. QA statement)
- Key result
- Parameter:
- thermal sensitivity - Koenen test: limiting diameter (mm)
- Remarks on result:
- not thermal sensitive if heated under defined confinement
- Key result
- Parameter:
- sensitiveness to impact: impact energy (J)
- Remarks on result:
- not sensitive to impact using an impact energy of 40 J
- Key result
- Parameter:
- sensitiveness to friction: friction load (N)
- Remarks on result:
- not sensitive to friction using a friction load of 360 N
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a study according to EU Test Method A.14 the substance showed no explosive properties.
- Executive summary:
In a study according to EU Test Method A.14 the substance showed no explosive properties. The test substance was not thermally sensitive, nor was it sensitive to shock or friction.
- Endpoint:
- explosiveness
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.14 (Explosive properties)
- GLP compliance:
- no
- Parameter:
- other: thermal sensitivity
- Remarks on result:
- negative (not further specified)
- Parameter:
- other: mechanical sensitivity (friction)
- Remarks on result:
- negative (not further specified)
- Parameter:
- other: mechanical sensitivity (shock)
- Remarks on result:
- negative (not further specified)
- Interpretation of results:
- non explosive
- Remarks:
- Migrated information
- Conclusions:
- In a study according to EU Test Method A.14 the substance showed no explosive properties.
- Executive summary:
In a study according to EU Test Method A.14 the substance showed no explosive properties.
- Endpoint:
- explosive properties of explosives
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The read-across is performed between two forms of the same substance. The identities of the two forms are describe below.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
The source form is 3,6-bis(4-chlorophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrol-1,4-dione (EC-no. 401-540-3), referred to here as PR254. PR254 is an organic mono-constituent substance with a typical purity of > 99.5% (w/w). It does not contain any impurity relevant for classification or labelling of the substance. The target form is the nanoform of the source substance, referred to here as PR254 nanoform. As the source form, it has a typical purity of > 99.5% (w/w) and it does not contain any impurity relevant for classification or labelling of the substance. The PR254 nanoform is spheroidal with a pure polyhedral shape and is not surface-treated.
3. ANALOGUE APPROACH JUSTIFICATION
The two analogue forms have the same structure. Under ambient atmosphere, the specific surface energy of particles increases with decreasing particle size. Therefore, particle aggregate to reach an energy minimum. The driving forces are hydrogen bonds and van der Waals forces (π-π interaction). Substantial energy is required to disperse the PR254 nanoform aggregates to particles that fall under the nanoform definition.
PR254 was been tested extensively addressing information requirements of Annexes VII to IX without identifying any biological target. PR254 nanoform could potentially have biological targets due to the different particle size distribution, which would require processes capable of dispersing the aggregates, e.g. in aqueous milieu. However, both forms have been tested according to OECD Test Guideline 318, demonstrating that PR254 nanoform cannot be dispersed under the condition of the study, i.e. immediately after sonification re-forms aggregates. Also, PR254 aggregates to a large extent, but can be more easily dispersed than the nanoform. The experiments demonstrated that exposure in aqueous milieu will be primarily to aggregates, regardless of the PR254 form.
Therefore, it is concluded that both forms will behave identically in studies, in which they are applied under atmospheric conditions and/or in aqueous milieus, so that for the PR254 nano-form no specific biological targets need to be considered.
Most physico-chemical properties (PCP) are inherent properties of a substance, which are not affected by the substance form. In addition, many PCP are determined starting the experimental procedure under ambient conditions, at which both forms have a similar particle size distribution. Therefore, the explosiveness will also be similar and the read-across from the source to the target form is scientifically justified.
4. DATA MATRIX
The data matrix is included as Annex 1 in the assessment report ‘PR254 bulk nano analogue approach 210111’ attached here below under ‘Attached justification’. - Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.14 (Explosive properties)
- GLP compliance:
- yes (incl. QA statement)
- Key result
- Parameter:
- thermal sensitivity - Koenen test: limiting diameter (mm)
- Remarks on result:
- not thermal sensitive if heated under defined confinement
- Key result
- Parameter:
- sensitiveness to impact: impact energy (J)
- Remarks on result:
- not sensitive to impact using an impact energy of 40 J
- Key result
- Parameter:
- sensitiveness to friction: friction load (N)
- Remarks on result:
- not sensitive to friction using a friction load of 360 N
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a study according to EU Test Method A.14 the substance showed no explosive properties.
- Executive summary:
In a study according to EU Test Method A.14 the substance showed no explosive properties. The test substance was not thermally sensitive, nor was it sensitive to shock or friction.
Referenceopen allclose all
Thermal sensitivity (effect of a flame):
Test no. | Nozzle-plate with 2 mm hole | Nozzle-plate with 6 mm hole | ||
explosion | number of fragments | explosion | number of fragments | |
1 | no | 0 | no | 0 |
2 | no | 0 | no | 0 |
3 | no | 0 | no | 0 |
The substance is not thermally sensitive.
Mechanical sensitivity (shock):
Test no. | Reaction |
1 | Negative |
2 | Negative |
3 | Negative |
4 | Negative |
5 | Negative |
6 | Negative |
The substance is not shock sensitive.
Mechanical sensitivity (friction):
Test no. | Reaction |
1 | Negative |
2 | Negative |
3 | Negative |
4 | Negative |
5 | Negative |
6 | Negative |
The substance is not sensitive to friction.
Decomposition occurs in the mechanical sensitivity (shock) test.
No explosion occurs in the mechanical sensitivity (friction) test.
No explosion occurs in the thermal sensitivity (effect of a flame) test.
Thermal sensitivity (effect of a flame):
Test no. | Nozzle-plate with 2 mm hole | Nozzle-plate with 6 mm hole | ||
explosion | number of fragments | explosion | number of fragments | |
1 | no | 0 | no | 0 |
2 | no | 0 | no | 0 |
3 | no | 0 | no | 0 |
The substance is not thermally sensitive.
Mechanical sensitivity (shock):
Test no. | Reaction |
1 | Negative |
2 | Negative |
3 | Negative |
4 | Negative |
5 | Negative |
6 | Negative |
The substance is not shock sensitive.
Mechanical sensitivity (friction):
Test no. | Reaction |
1 | Negative |
2 | Negative |
3 | Negative |
4 | Negative |
5 | Negative |
6 | Negative |
The substance is not sensitive to friction.
Description of key information
The substance has no explosive properties.
Key value for chemical safety assessment
- Explosiveness:
- non explosive
Additional information
In two reliable studies (without or with limitation) according to EU Test Method A.14, the
substance showed no exploive properties.
The test substance was not thermally sensitive, nor was it sensitive to shock or friction.
Justification for classification or non-classification
As the substance was not explosive in two tests according to EU Test Method A.14, no classification is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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