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Diss Factsheets
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EC number: 202-852-0 | CAS number: 100-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not a Guideline study. Used 4 strains of Salmonella typhimurium, but did not use E. coli strain of bacteria. Four concentrations of test material were used, rather than 5.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- only utilized 4 strains of Salmonella typhimurium
- Principles of method if other than guideline:
- Similar to Guideline 471. Rather than using the standard positive controls, the authors used styrene and 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone which served as controls for an in vivo segment of the study.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 4-vinylpyridine
- EC Number:
- 202-852-0
- EC Name:
- 4-vinylpyridine
- Cas Number:
- 100-43-6
- Molecular formula:
- C7H7N
- IUPAC Name:
- 4-ethenylpyridine
- Test material form:
- other: liquid
- Details on test material:
- 4-Vinylpyridine obtained commercially and purified by precipitation in 1% HCL/acetone (v/v). Purity was greater than 99% as checked by GC-FID.
Constituent 1
Method
- Target gene:
- histidine
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- liver of rodents induced with Arochlor.
- Test concentrations with justification for top dose:
- 2.5, 5.0, 7.5 and 10 micromol/plate, approximately equivalent to levels up to a concentration of 5000 ul/plate
- Vehicle / solvent:
- DMSO
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- dimethyl sulfoxide
- True negative controls:
- no
- Positive controls:
- yes
- Remarks:
- NNK and styrene
- Remarks:
- part of an in vivo study using these positive controls
- Details on test system and experimental conditions:
- Used tester strains TA 1535, TA 1538, TA 98 And TA 100, with and without metabolic activation by Arochlor-induced S9 fraction. Concentration of S9 fraction added was not given. Strain of rodent for liver S9 fraction not given.
- Evaluation criteria:
- Comparison was made between mutation frequency in treated groups and vehicle controls. The mutation frequency in positive controls indicated the test was working properly.
- Statistics:
- Statistical significance was evaluated using the Student's t-test.
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- at 25 and 50 micromol/plate
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- Toxicity to bacteria was exhibited by 4-vinylpyridine. At 5 and 10 micromol/plate, survival was 10-30%.
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
4-Vinylpyridine was not mutagenic to Salmonella strains under the conditions of this assay.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with and without metabolic activation
4-Vinylpyridine was not mutagenic to Salmonella strains TA 1535, TA 1538, TA 98 and TA 100, with and without metabolic activation, under the conditions of this assay. - Executive summary:
4-Vinylpyridine was tested in a standard Ames bacterial mutagenicity study using Salmonella strains TA 1535, TA 1538, TA 98 and TA 100, with and without metabolic activation. Under the conditions of this assay, the substance was not mutagenic.
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