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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 618-126-5 | CAS number: 88196-70-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline conducted according to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD TG 431
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 62409-13-6
- Cas Number:
- 62409-13-6
- IUPAC Name:
- 62409-13-6
Constituent 1
Test system
- Duration of treatment / exposure:
- 3 minutes and 1 hour
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: cell viability
- Value:
- ca. 92
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 3 min. Reversibility: other: not applicable. Remarks: score = viability [% of negative control]. (migrated information)
- Irritation / corrosion parameter:
- other: other: cell viability
- Value:
- ca. 9
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 1 h. Reversibility: other: not applicable. Remarks: score = viability [% of negative control]. (migrated information)
Applicant's summary and conclusion
- Conclusions:
- Based on the observed results and applying the evaluation criteria it was concluded, that rac-1-(3-Methoxyphenyl)ethylamine shows a corrosive potential in the EpiDerm skin corrosivity test under the test conditions chosen. The test method does not yet allow for the differentiation of severity of the effect. The results however indicate moderate corrosivity. For final assignment of a risk phrase at present, further evidence or results from an in vivo study would be needed.
- Executive summary:
The potential of rac-1-(3-Methoxyphenyl)ethylamine to cause dermal corrosion was assessed by a single topical application of 50 μL of the test substance to a reconstructed three dimensional human epidermis model (EpiDerm™). Two EpiDerm™ tissue samples were incubated with the test substance for 3 minutes and 1 hour, each. Tissue destruction was determined by measuring the metabolic activity of the tissue after exposure using a colorimetric test. The reduction of mitochondrial dehydrogenase activity, measured by reduced formazan production after incubation with a tetrazolium salt (MTT) was chosen as suitable endpoint. The formazan production of the test-substance treated epidermal tissues is compared to that of negative control tissues. The quotient of both values indicates the
relative tissue viability. The EpiDerm skin corrosivity test showed the following results:
The test substance is able to directly reduce MTT. However, this ability of direct MTT reduction did not impair the study result as demonstrated by the concurrently performed exposure of control tissues inactivated by freezing. Viability of the test-substance treated tissues determined after an exposure period of 3 minutes was 92%. Viability of the test-substance treated tissues determined after an exposure period of 1 hour was 9%. Based on the observed results and applying the evaluation criteria it was concluded, that rac-1-(3-Methoxyphenyl)ethylamine shows a corrosive potential in the EpiDerm™ skin corrosivity test under the test conditions chosen. The test method does not yet allow for the differentiation of severity of the effect. The results however indicate moderate corrosivity. For final assignment of a risk phrase at present, further evidence or results from an in vivo study would be needed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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