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EC number: 203-910-8 | CAS number: 111-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-05-17 till 1984-10-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: French Guideline NF T 03.021 from 1980
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl undec-10-enoate
- EC Number:
- 203-910-8
- EC Name:
- Methyl undec-10-enoate
- Cas Number:
- 111-81-9
- Molecular formula:
- C12H22O2
- IUPAC Name:
- methyl undec-10-enoate
- Reference substance name:
- 2023-910-8
- IUPAC Name:
- 2023-910-8
- Details on test material:
- - Name of test material (as cited in study report): UNDECYLENATE DE METHYLE
- Substance type: organic
- Physical state: clear yellowish liquid
- Analytical purity: 98%
- Impurities (identity and concentrations): no data
- Purity test date: 24.02.84
- Lot/batch No.: UNDECYLENATE DE METHYLE, Analyse 151
- Expiration date of the lot/batch: no data
- Stability under test conditions: not reported
- Storage condition of test material: not reported
- Other:
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River France (76410, Saint Aubin les Elbeuf - France)
- Age: no data
- Weight at study initiation: 199g (males), 187g (females)
- Fasting period before study: no data
- Housing: 5 animals of same sex were housed in one polycarbonate cage with stainless top
- Diet (e.g. ad libitum): pelleted rat diet "Expanded SQC" (Special Diets Services Ltd, Witham, Essex, England)
- Water (e.g. ad libitum): potable water filtered through Millipore membrane, ad libitum
- Acclimation period: min. 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C ± 3°C
- Humidity (%): 50 % ± 20%
- Air changes (per hr): air was not recycled, air was filtered
- Photoperiod (hrs dark / hrs light): 12 h / 12 h
IN-LIFE DATES: From: 1984-05-17 To: 1984-07-31
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE: not applicable
MAXIMUM DOSE VOLUME APPLIED: 5.7 ml/kg
DOSAGE PREPARATION (if unusual):
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: - Doses:
- 620, 1240, 1860, 2570 mg/kg body weight (pre-test 5000 mg/ kg bw)
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical observations frequently directly after test item application, and twice a day thereafter; body weight measurement just before test item application, and at days 4, 7, and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- no statistics applied
Results and discussion
- Preliminary study:
- 5000 mg/kg bw: animals are in state of coma one hour after test item application.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 563 mg/kg bw
- 95% CL:
- >= 1 225 - <= 1 875
- Mortality:
- Number and date of deaths at each dose:
At 620 mg/kg: no death
At 1240 mg/kg: 2 dead animals on day 1
At 1860 mg/kg: 8 dead animals 3 hours after treatment
At 2570 mg/kg: 9 dead animals 3 hours after treatment - Clinical signs:
- other: At 620 mg/kg: no symptom At 1240 mg/kg: hypokinesia on day 1, then no symptom At 1860 mg/kg: hypokinesia and sedation on day 1, pilo-erection from D1 to D6, then no symptom. At 2570 mg/kg: sedation on day 1, then no symptom. One male went into a coma
- Gross pathology:
- Due to absence of any macroscopally visible lesions, no further histopathologic investigations
- Other findings:
- - Organ weights: no abnormalities reported
- Histopathology: not investigated (see above)
- Potential target organs: not investigated
- Other observations:
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Guidance to regulation (EC) No 1272/2008 on CLP of substances and mixtures.
- Conclusions:
- LD50 is assessed at 1563 mg/kg (95% CL 1225-1875 mg/kg). Symptoms start to appear within 15 min after treatment at the dose of 1248 mg/kg and above (hypokinesia, sedation and coma). Mortality appears 3 hours after treatment, until day 1. Acc. to UN-GHS, the test item UNDECYLENATE DE METHYLE is classified as acute toxic (oral) category 4.
- Executive summary:
LD50 is assessed at 1563 mg/kg (95% CL 1225-1875 mg/kg). Symptoms start to appear within 15 min after treatment at the dose of 1248 mg/kg and above (hypokinesia, sedation and coma). Mortality appears 3 hours after treatment, until day 1. Acc. to UN-GHS, the test item UNDECYLENATE DE METHYLE is classified as acute toxic (oral) category 4.
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