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EC number: 605-539-0 | CAS number: 169115-74-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
Description of key information
The vapour pressures of carbamic acid, (2-hydroxypropyl)-, compd. with 1-amino-2-propanol (1:1) were determined as 6 hPa at 20 °C, 53 hPa at 50 °C and 85 hPa at 55 °C.
The vapour pressure of 1 -amino-2 -propanol was predicted using the QSAR calculation of the Estimation Programm Interface EPI-Suite v4.1. The experimental melting point of 25 °C and boiling point of 160 °C (at 1013 hPa) were taken into account for estimation. Using the modified Grain method, the vapour pressure was estimated to be 91.4 Pa at 25°C.
The vapour pressure of ethylene glycol was predicted using the QSAR calculation of the Estimation Programm Interface EPI-Suite v4.1. The experimental boiling point of 197.3 °C (at 1013 hPa) was taken into account for estimation. Using the modified Grain method, the vapour pressure was estimated to be 7.24 Pa at 25 °C.
The vapour pressure of 2 -hydroxypropylcarbamic acid was predicted using the QSAR calculation of the Estimation Programm Interface EPI-Suite v4.1. The calculated melting point of 57.52 °C and boiling point of 257.06 °C were taken into account for estimation. Using the modified Grain method, the vapour pressure was estimated to be 0.136 Pa at 25 °C.
The predicted value can be considered reliable yielding a useful result for further assessment.
Key value for chemical safety assessment
- Vapour pressure:
- 6 hPa
- at the temperature of:
- 20 °C
Additional information
Additional information for measured data
The manufacturing process of carbamic acid, (2-hydroxypropyl)-, compound with 1-amino-2-propanol (1:1) runs solvent-based in ethylene glycol and the compound has to be continuously dissolved in about 50% ethylene glycol to ensure stability. This is the only form how the active compound carbamic acid, (2-hydroxypropyl)-, compound with 1-amino-2-propanol (1:1) can be handled and this is also the only marketed form. Because of this instability toxicological investigations cannot be performed with the ‘active ingredient’ but have to be performed with the solution in ethylene glycol. The trade name of the solubilized product is Zusatzmittel 19IF00 A.
Additional information for evaluation fo measured data and QSAR
The substance contains about 50% solvent (ethyleneglycol) and about 50% of active ingredient. It was assumed that the measured vapour pressure is mainly triggered by the solvent. However, QSAR estimations indicate that one of the substance components (1 -amino-2 -propanol) has the highest vapour pressure which is close to the measured value. Therefore, the measured vapour pressure can be assumed to be true for the active ingredient.
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