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Diss Factsheets
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EC number: 701-374-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Comparable to OECD 203 with the exception of a 3-day fast prior to exposure rather than a fast of 24-hours. The exposure duration was 48-hours, not 96-hours as preferred per the study guideline. Study was run at a concentration well in excess of the water solubility limit.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reaction products of triphenyl phosphite and isodecanol (1:2)
- EC Number:
- 701-374-4
- Cas Number:
- 25550-98-5
- Molecular formula:
- C26H47O3P
- IUPAC Name:
- Reaction products of triphenyl phosphite and isodecanol (1:2)
- Details on test material:
- - Name of test substance: Irgastab CH 300 (CAS# 25550-98-5)
- Commercial purity: Not stated
- Lot/batch No.: 928 (Test article identification code: TK 11211)
- Supplier: Ciba-Geigy, Ltd, Basel, Switzerland
Constituent 1
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- The test substance was prepared by dissolving 5.0 g into 50 mL of DMSO. No analytical calculations of test concentrations were performed, but the material appeared to be homogeneously distributed.
Test organisms
- Test organisms (species):
- Leuciscus idus
- Details on test organisms:
- - Common name: Golden Orfe
- Source: P. Hohler, Zeiningen, Switzerland
- Length at study initiation: 44 mm (35-50 mm)
- Weight at study initiation: 0.59 g (0.29-0.85g).
- Feeding during test: None
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 254 mg CaCO3/L
- Test temperature:
- 21 +/- 1oC.
- pH:
- 7.8 to 8.1
- Dissolved oxygen:
- 97-98 % at 0 hours, 84-94% at 24 hours, and 93-99% at 48 hours
- Nominal and measured concentrations:
- The highest concentration of test substance in water was determined to be 100 mg/L, based on visible precipitate immediately forming at concentrations above this value. (Nominal concentration)
- Details on test conditions:
- Calculated amounts of the test substance to produce the desired test concentrations were added into the water and were homogeneously distributed. The fish were transferred into the tank for a total duration of 48 hours.
TEST SYSTEM
- Test vessel: 20-L tank
- Aeration: Gentle aeration during the test
- No. of organisms per vessel: Ten fish
- No. of vessels per concentration (replicates): Duplicate test article groups were used and compared to that of concurrent blank (water) and vehicle control
- Biomass loading rate: 0.39 g fish/L water.
OTHER TEST CONDITIONS
- Photoperiod: 16-hours daily were used.
- Light intensity: fluorescent light
EFFECT PARAMETERS MEASURED: Signs and symptoms of toxicity and mortality were recorded at 24 and 48 hours.
VEHICLE CONTROL PERFORMED: yes, 1101 mg DMSO/L water
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: no effects
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- No effects were observed up to a maximum loading level of 100 mg/L. This study was run at concentrations well above the water solubility limit; however, since there are no signs of toxicity even at such a high concentration the study is acceptable to establishing that this phosphite is not toxic to fish.
- Executive summary:
No effects were observed up to a maximum loading level of 100 mg/L (above the estimated solubility limit).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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