Registration Dossier
Registration Dossier
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EC number: 402-140-1 | CAS number: 17865-32-6 CHMMS; CHMS; DYNASYLAN 9407; Z-6187
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable short-term toxicity test results are available for freshwater fish (O. mykiss),invertebrates (D. magna) and algae (D. subspicatus). LC50or EC50values for the three organisms are 24 (geom. mean parent substance), 13 (geom. mean parent substance) and 45 mg/l (nominal parent substance) respectively. A NOEC of 12.5 mg/l has been determined in the algal test. It is likely that the test organisms were predominantly exposed to a mixture of the parent compound and hydrolysis product in the fish semi-static test.
Analysis of parent substance in test media by gas chromatography was undertaken as part of the fish, invertebrates and algal inhibition studies performed using this substance (SafePharm Laboratories Ltd. 1996c, 1996d and 1996e respectively). The studies suggest that the half-life of the substance is approximately 24 hours at 14°C and pH 7 in the fish study, and approximately 24 hours at 21°C and pH 7-8 in the freshwater invertebrate study. The hydrolysis rate appears to be faster in the algal study where the parent substance could not be traced in solution after 72 hours. The temperature of the algal study was 24°C and the pH range was 8 to 10. This is limited evidence for understanding of the half-life, but may be indicative.
No toxicity to microorganisms data are available for the parent substance or the hydrolysis product. For the parent substance, weight of evidence data from three respiration inhibition tests for the structurally-related substance, dicyclopentyldimethoxysilane, has been read-across (EC50 >1000mg/l). For the hydrolysis product, data for an activated sludge respiration inhibitiontest fora structurally-related substance, dicyclopentyldichlorosilane, has been read-across (EC50 >100 mg/l (nominal)).
Data waivers for long-term toxicity endpoints are applicable.
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