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EC number: 800-991-7 | CAS number: 1427388-03-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 19th September 2003 and 30th October 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: November 2002 Date of signature: March 2003
Test material
- Reference substance name:
- 86273-46-3
- Cas Number:
- 86273-46-3
- IUPAC Name:
- 86273-46-3
- Reference substance name:
- -
- EC Number:
- 451-690-9
- EC Name:
- -
- Reference substance name:
- 2-(2-Vinyloxyethoxy) ethyl acrylate
- IUPAC Name:
- 2-(2-Vinyloxyethoxy) ethyl acrylate
- Reference substance name:
- 2-Propenoic acid, 2-[2-(ethenyloxy)ethoxy]ethyl ester
- IUPAC Name:
- 2-Propenoic acid, 2-[2-(ethenyloxy)ethoxy]ethyl ester
- Details on test material:
- - Name of test material (as cited in study report): 2-(2'-vinyloxyethoxyl)ethyl acrylate and VEEA
- Substance type: Liquid
- Physical state: Transparent liquid
- Analytical purity: 99%
- Lot/batch No.: FX02T15
- Storage condition of test material: Store in a dark, cool place.
other: Wear suitable protective clothing,
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Elevage Scientifique des Dombes, F-01400 Chatillon sur Charlaronne, France
Harlan UK Limited, Bicester, Oxon, UK
- Age at study initiation:
11 weeks male
12 - 13 weeks females
- Weight at study initiation:
2259g to 2292g
- Housing:
The animals were individually housed in stainless steel cages.
- Diet (e.g. ad libitum):
ad libitum - pelleted standard Provimi Kliba 3418 rabbit maintenance diet.
- Water (e.g. ad libitum):
ad libitum, community tap water.
- Acclimation period:
Under laboratory conditions after health examination. Only animals without any visual signs of illness were used for the study.
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
17 to 23°C
- Humidity (%):
30 to 70%
- Air changes (per hr):
10 - 15 changes per hour
- Photoperiod (hrs dark / hrs light):
Twelve hours continuous light followed by twelve hours darkness
IN-LIFE DATES:
From: day 1 To:day 3
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The right eye remained untreated and served as a reference control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):
A volume of 0.1 ml of the test material was placed into the conjunctival sac of the left eye, formed by gently pulling the lower lid away from the eyeball.
- Concentration (if solution):
Undiluted and used as supplied
VEHICLE
- Amount(s) applied (volume or weight with unit):
Not applicable
- Concentration (if solution):
Not applicable
- Lot/batch no. (if required):
Not applicable
- Purity:
Not reported
EXAMPLE - Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- Approximately 1, 24, 48 and 72 hours following treatment
- Number of animals or in vitro replicates:
- As it was suspected that the test item might produce irritancy, a single animal (one female) was treated first. As neither a corrosive effect nor a severe irritant effect was observed after the 1 and 24-hour examinations, the test was completed using the two remaining animals.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done):
Not applicable
- Time after start of exposure:
Not applicable
SCORING SYSTEM:
Assessment of ocular damage/irritation was made approximately 1, 24, 48 and 72 hours following treatment, according to the numerical evaluation given in attachment 1. The classification system used in this study was the EU classification and labelling guide.
TOOL USED TO ASSESS SCORE:
Examination of the eye was facilitated by the use of a Varta Cliptrix diagnostic-lamp.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- animal: Male 76
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal: Female 77
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal: Female 78
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Irritation parameter:
- cornea opacity score
- Remarks:
- Male 76
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: No effect observed
- Irritation parameter:
- cornea opacity score
- Remarks:
- Female 77
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect observed
- Irritation parameter:
- cornea opacity score
- Remarks:
- Female 78
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: np effect observed
- Irritation parameter:
- iris score
- Remarks:
- Female 78
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect observed
- Irritation parameter:
- iris score
- Remarks:
- Female 77
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect observed
- Irritation parameter:
- iris score
- Remarks:
- Male 76
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect observed
- Irritation parameter:
- conjunctivae score
- Remarks:
- Male 76
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: max score was seen at the 24 hour mark
- Irritation parameter:
- conjunctivae score
- Remarks:
- Female 77
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: max score seen at 24 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- Female 78
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: max score seen at 24 hours
- Irritant / corrosive response data:
- Ocular Reactions
Individual and group mean scores for ocular irritation are given in Table 1 and Table 2.
No corneal effects were noted during the study.
Iridial inflammation was not noted during the study.
Moderate conjunctival irritation was noted in all treated eyes at one, 24 and 48 hours after treatment with minimal conjunctival irritation noted at the 72 hour observation mark in 2 out of the 3 animals. - Other effects:
- Body weight
All animals showed expected gain in bodyweight during the study.
Any other information on results incl. tables
No clinical signs of systemic toxicity were observed in the animals during the study and no mortality occurred.
Irritation:
The mean score was calculated across 3 scoring times (24, 48 and 72 hours after instillation) for each animal for corneal opacity, iris, redness and chemosis od the conjunctivae, separately. The individual mean scores for corneal opacity and iris were 0 for all 3 animals. The individual mean scores for the conjunctivae were 1.33, t 72 hours treatment.
Slight to moderate occular discharge was observed in all animals at the 1 -hour reading.
No abnormal findings were observed in the treated eye of any animals 7 days after treatment, the end of the observation period for all animals.
Coloration:
No staining of the treated eyes produced by the test item was observed
Corrosion:
No corrosion of the cornea was observed at any of the reading times.
Body weights:
The body weights of all rabbits were considered to be within the normal range of variability.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on this OECD 405 study,, 2-(2'Vinyloxy ethoxy) ethyl acrylate is considered to be "not irritating" to the rabbit eye.
- Executive summary:
Eye irritation:
The Primary eye irritation potential of 2 -(2'-Vinyloxy ethosy) ethyl acrylate was investigated according to OECD guideline test no. 405. The test item was applied by instillation of 0.1mL into the left eye of each of three young adult New Zealand White rabbits. Scoring of irritation effects was performed approximately 1, 24, 48 and 72 hours after test item instillation.
The mean score was calculated across 3 scoring items (24, 48 and 72 hours after instillation) for each animal for corneal opacity, iris, redness and chemosis of the conjuctivae, separately. The individual mean scores for corneal opacity and iris were 0 for all three animals. The individual mean scores for the conjuctivae were 1.33, 1.33 and 1.00 for reddening and 0, 0 and 0.33 for chemosis respectively.
The instillation of 2 -(2'-Vinyloxyethoxy) ethyl acrylate into the eye resulted in mild, early onset and transient occular changes, such as reddening of the conjuctivae and sclerae, discharge and chemosis. These effects were reversible and were no longer evident 7 days after treatment, the end of the observation period for all animals. No abnormal findings were observed in the cornea or iris of any animal at any of the examinations. No corrosion was observed at any of the measuring intervals. No staining of the treated eyes by the test item was observed and no other clinical signs of test item related effects were observed.
Thus, the test item did not induce significant or irreversible damage to the rabbit eye.
Based upon the referred classification criteria (Commission Directive 2001/59/EC of August 06, 2001), 2 -(2'-Vinyloxy ethoxy) ethyl acrylate is considered to be "not irritating" to the rabbit eye.
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