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Diss Factsheets
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EC number: 610-915-2 | CAS number: 52937-90-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable study performed according to scientific standards
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- publication
- Title:
- Acute Toxicologic Evaluation of 3-Amino-2-butenoic acid isobutylester
- Author:
- Bomhard E, Ramm W
- Bibliographic source:
- Int. J. Toxicol. 19 337, 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 84/449/EWG (Amtsblatt der Europäischen Gemeinschaften Nr. L 251 vom 19.09.1984, S. 96)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- isobutyl (2Z)-3-aminobut-2-enoate
- EC Number:
- 610-915-2
- Cas Number:
- 52937-90-3
- Molecular formula:
- C8 H15 N O2
- IUPAC Name:
- isobutyl (2Z)-3-aminobut-2-enoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann, Borchen, Germany
- Strain: Bor:WISW (SPF Cpb)
- Age at study initiation: adult mean (173 g males - 175 g females)
- Diet: ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol (PEG 400)
- Details on oral exposure:
- - Application volume: 20 mL/kg bw
- Doses:
- 1000, 1300, 1600, 2000, and 2500 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: at least once daily (clinical signs, mortality) or once weekly (weight gain)
- Necropsy of survivors performed: yes - Statistics:
- Rosiello et al, J. Tox and Environ. Health 3, 797-809, 1977
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1000 mg/kg bw: 0/5 males, 0/5 females
1300 mg/kg bw: 3/5 males, 2/5 females
1600 mg/kg bw: 4/5 males, 2/5 females
2000 mg/kg bw: 4/5 males, 4/5 females
2500 mg/kg bw: 5/5 males, 5/5 females - Clinical signs:
- other: doses of 1300 mg/kg and above: poor general condition, dazed condition, abdominal or lateral position, piloerection; on day 4 signs had disappeared
- Gross pathology:
- At necropsy dead animals showed loss of gastric mucosal relief, the stomach fundus and the intestines were reddened; final necropsy at day 14 revealed no abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
- Executive summary:
The acute oral toxicity of 3 -Aminocrotonsäurebutylester was determined with an LD50 value of 1400 mg/kg bw in rats. Doses of 1000 up to 2500 mg/kg bw were tested in groups of 5 male and 5 female rats. Mortality occurred at doses of 1300 mg/kg bw and above. All animals in the 2500 mg/kg bw group died. Thus, the test item should be considered as harmful after oral uptake.
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