Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 690-526-2 | CAS number: 38632-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guidelinestudy
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Principles of method if other than guideline:
- An acute oral toxicity study according OECD TG 423 was conducted. 2x3 female rats received a single dose of X-TAN (preparation of hexamethylen diisocyanatebisulfite-adducte in water). Clinical signs and mortality rates were determined several times on the day of administration and subsequently at least once daily for an observation period of at least 14 days. The weight gain ofthe animals was checked weekly until the end ofthe study. Animals which died or were killed in moribund state were weighed (except on day of administration) and dissected as so on as possible, and examined macroscopically.
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Methansulfonic acid (1,6-hexanediyl-diimino)bis[1-oxo, disodium salt
- EC Number:
- 690-526-2
- Cas Number:
- 38632-47-2
- Molecular formula:
- C8H14S2N2O8.Na2
- IUPAC Name:
- Methansulfonic acid (1,6-hexanediyl-diimino)bis[1-oxo, disodium salt
- Details on test material:
- Content of active substance was 31.94% (not used for calculation)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 2 x 3 animals per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- other: cut-offm LD50
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality or clinical signs observed at 2000 mg/kg of a 31% X-Tan solution of. This corresponds to a cut-off LD50 of >= 5000 mg/kg according to Annex 2d in the OECD TG 423, which corresponds to a cut-off LD50 of 1598 mg/kg for the active ingrediant.
Applicant's summary and conclusion
- Executive summary:
An acute oral toxicity study according OECD TG 423 was conducted. Two x three female rats received a single dose of X-TAN (preparation of hexamethylen diisocyanatebisulfite-adducte in water). Clinical signs and mortality rates were determined several times on the day of administration and subsequently at least once daily for an observation period of at least 14 days. The weight gain ofthe animals was checked weekly until the end ofthe study. Animals which died or were killed in moribund state were weighed (except on day of administration) and dissected as so on as possible, and examined macroscopically.
A dose of 2000 mg/kg body weight (content of active substance was not used for calculation) was tolerated by female rats without mortalities, clinical signs, toxicological effects on weight gain and gross pathological findings.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.