Registration Dossier
Registration Dossier
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EC number: 610-545-1 | CAS number: 50588-42-6
Endpoint summary
Administrative data
Description of key information
No studies are available for didenac and information is based on read across to a similar substance, dienone. Based on read across to dienone, the oral discriminating dose for didenac is considered to be 500 mg/kg bw in male and female rats. The dermal LD50 is >2000 mg/kg in male and female rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 500 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- mg/kg bw
Additional information
Read-across justification summary is attached to this endpoint summary.
Based on read across to dienone, the oral discriminating dose for didenac is considered to be 500 mg/kg bw in male and female rats. The dermal LD50 is >2000 mg/kg in male and female rats.
Justification for selection of acute toxicity – oral endpoint
Only acute oral toxicity value. Discriminating dose for didenac, by read-across to dienone, is 500 mg/kg bw.
Justification for selection of acute toxicity – dermal endpoint
Only acute dermal toxicity value. LD50 for didenac, by read-across to dienone, is >2,000 mg/kg bw.
Justification for classification or non-classification
Based on read across to dienone and according to the Directive 67/548 EEC, didenac is classified: Xn, R22 - Harmful if swallowed and as Acute Oral Category 4 according to Regulation (EC) 1272/2008 (CLP).
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