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EC number: 211-910-4 | CAS number: 709-55-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.3110 (Ready Biodegradability)
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Directive 92/69/EEC, Method C.4-D of July 31, 1992: Manometric Respirometry Test (EEC Publication No. L 383 A, December 1992)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Etilefrine
- EC Number:
- 211-910-4
- EC Name:
- Etilefrine
- Cas Number:
- 709-55-7
- Molecular formula:
- C10H15NO2
- IUPAC Name:
- 3-[2-(ethylamino)-1-hydroxyethyl]phenol
- Details on test material:
- Name : Effortil-Rohbase
Batch No.: 310
Aggregate State at RT: solid
Colour: white
Purity: >98%
Analysis: meldting point
Certificate of Analysis: 19.07.2000
Sorage: in original container, at room temperature, in the dark
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, adapted
- Details on inoculum:
- Species
activated sludge, micro organisms from a domestic waste water treatment plant
Origin
supplied by the sewage plant Groß-Zimmern, Germany
Conditioning
The activated sludge used for this study was washed by centrifugation and the supernatant liquid phase was decanted. The solid material was resuspended in tap water and again centrifuged. This procedure was repeated twice. An aliquot of the final sludge suspension was weighed, dried and the ratio of wet sludge to its dry weight was determined. Based an this ratio, calculated aliquots of washed sludge suspension, corresponding to 1.5 g dry material per litre were mixed with test water and then aerated until use. - Duration of test (contact time):
- > 0 - <= 28 d
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- The change of pressure in the test flasks was measured by means of a manometric method (BSB/BOD-Sensor-System, Aqualytic, D-63263 Neu Isenburg, Germany) each day.
Reference substance
- Reference substance:
- aniline
Results and discussion
- Preliminary study:
- Biodegradation of Reference Item Aniline
The reference item Aniline was sufficiently degraded to 87% after 14 days, and to 101 % after 28 days of incubation. The percentage biodegradation of the reference item confirms the suitability of the used activated sludge inocolum.
% Degradationopen allclose all
- Parameter:
- other: ThODNH4
- Value:
- > 34 - < 48
- Sampling time:
- 10 d
- Parameter:
- other: ThODNH4
- Value:
- > 58 - < 62
- Sampling time:
- 28 d
- Parameter:
- other: ThODN03
- Value:
- > 50 - < 53
- Sampling time:
- 28 d
- Details on results:
- Biodegradation of Test Item
After correction of the mean biochemical oxygen demand of the inoculum controls at the end of the 28-day exposure period degradation rates of 58 % and 62 %, based on ThODNH4, were found. At the end of the 10-day window biodegradation rates of 34 % and 48 % were determined. Thus, the percentage biodegradation did not exceed 60 % within the 10-day window.
If the calculation of biodegradation is based on ThODNO3, percentage biodegradation reached 50 % and 53 % after 28 days of incubation.
BOD5 / COD results
- Results with reference substance:
- Biodegradation in the Toxicity Control
In the toxicity control containing both, the test item and the reference item Aniline, 43 % biodegradation was noted within 14 days and 53 biodegradation was determined after 28 days of incubation.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not considered to be ready biodegradable
- Executive summary:
Title: Ready Biodegradability of Effortil-Rohbase in a Manometric Respirometry Test
Guidelines/Recommendations: - Commission Directive 92/69/EEC, Method C.4-D of July 31,1992: Manometric Respirometry Test (EEC Publication No. L 383 A, December 1992)
- OECD Guideline for Testing of Chemicals No. 301 F: "Ready Biodegradability: Manometric Respirometry Test", adopted July 17, 1992
- EPA Guideline 712-C-98-076: OPPTS 835.3110, "Ready Biodegradability", January 1998.
Purpose: The test item Effortil-Rohbase was investigated for its ready biodegradability in a Manometric Respirometry Test over a period of 28 days. The biodegradation was followed by the oxygen uptake of the micro organisms during exposure. As a reference item Aniline was tested simultaneously under the same conditions as the test item, and functioned as a procedure control.
Results:
Biodegradation of Effortil-Rohbase: After correction of the mean biochemical oxygen demand of inoculum controls at the end of the 28-day exposure period degradation rates of 58 % and 62 %, based on ThODNH4, were found. At the end of the 10-day window biodegradation rates of 34 % and 48 % were determined. Thus, the percentage biodegradation did not exceed 60 % within the 10-day window. The test item can therefore not considered to be ready biodegradable. If the calculation of biodegradation is based on ThODNO3, percentage biodegradation reached 50 % and 53 % after 28 days of incubation.
Biodegradation of Aniline: The reference item Aniline was sufficiently degraded to 87 % after 14 days, and to 101 % after 28 days of incubation, thus confirming the suitability of the used activated sludge inoculum
Biodegradation in the Toxicity Control: In the toxicity control containing both, the test item and the reference item Aniline, 43 % biodegradation was noted within 14 days and 53 % biodegradation was determined after 28 days of incubation. Thus, the test item can be assumed to be not inhibitory on the activated sludge micro organisms.
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