Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-618-7 | CAS number: 39202-17-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- weight of evidence
- Study period:
- Not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- A well documented finite dose skin permeation calculator provided by US NIOSH. The LogKow for 9DDAME (5.91) is outside the limits for this model (max = 5.0). Hence a Log Kow of 5.0 has been used to run the model. This is thought to produce a more conservative result.
Data source
Reference
- Reference Type:
- other: Mathematical model
- Title:
- Finite Dose Skin Permeation Calculator
- Author:
- NIOSH
- Year:
- 2 013
- Bibliographic source:
- www.cdc.gov/niosh/topics/skin/finiteskinpermcalc.html
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- This calculator estimates flux, skin concentrations, and amounts absorbed from any size dose applied to partially or fully hydrated skin. Calculations are based on the model described in the following references:
1. Kasting, G. B. and M. A. Miller (2006). "Kinetics of finite dose absorption through skin 2. Volatile compounds." Journal of Pharmaceutical Sciences 95(2): 268-280.
2. Miller, M. A. and G. B. Kasting (2010). "Toward a Better Understanding of Pesticide Dermal Absorption: Diffusion Model Analysis of Parathion Absorption in Vitro and in Vivo." Journal of Toxicology and Environmental Health 73(4): 284 - 300.
3. Kasting, G. B., M. A. Miller, et al. (2008). "A Spreadsheet-Based Method for Estimating the Skin Disposition of Volatile Compounds: Application to N,N-Diethyl-m-Toluamide (DEET)." Journal of Occupational and Environmental Hygiene 5(10): 633-644.
4. Wang, T.-F., G. B. Kasting, et al. (2007). "A multi phase microscopic model for stratum corneum permeability. II. Estimation of physicochemical parameters and application to a large permeability database." Journal of Pharmaceutical Sciences 96(11): 3024-3051. - GLP compliance:
- no
Test material
- Reference substance name:
- methyl dodec-9-enoate
- EC Number:
- 700-618-7
- Cas Number:
- 39202-17-0
- Molecular formula:
- C13H24O2
- IUPAC Name:
- methyl dodec-9-enoate
Constituent 1
Test animals
- Species:
- other: Predicted human
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 8 hours
- Doses:
- 5 mg/cm2
Results and discussion
Percutaneous absorption
- Dose:
- 5 mg/cm2
- Parameter:
- percentage
- Absorption:
- 0.002 %
- Remarks on result:
- other: 8 hours
- Remarks:
- Calculated. See Other Information below
Any other information on results incl. tables
Calculated Permeant Distribution |
|||
Removed |
0.0 % |
0.0 |
μg/cm² |
Evaporated |
3.44 % |
172.218 |
μg/cm² |
Surface |
96.53 % |
4826.447 |
μg/cm² |
Stratum Corneum |
1.01E-02 % |
0.506 |
μg/cm² |
Viable Epidermis |
4.87E-03 % |
0.244 |
μg/cm² |
Dermis |
1.22E-02 % |
0.608 |
μg/cm² |
Systemically Absorbed |
1.65E-03 % |
0.082 |
μg/cm² |
Total |
100.00 % |
5000.000 |
μg/cm² |
Applicant's summary and conclusion
- Executive summary:
Using the US NIOSH Finite Dose Skin Permeation Calculator, systemic absorption of 9 -dodecenoic acid, methyl ester across partially hydrated human skin is predicted to be very low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.