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EC number: 203-354-6 | CAS number: 106-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Read-across approach (EC Number: 422-320-3); two soil macroorganism endpoints were located:
- Acute study, OECD Guideline 207, GLP, key study, validity 1, Eisenia foetida: 14d-LC50 > 1000 mg/kg soil dw (based on nominal concentration), NOEC >= 1000 mg/kg soil dw (based on nominal concentration). No effects at the highest concentration tested.
- Chronic study, OECD Guideline 222, GLP, key study, validity 2, Eisenia foetida: 56d-LOEC > 544 mg/kg soil dw (based on initial measured concentration), 56d-NOEC >= 544 mg/kg soil dw (based on initial measured concentration). No effects at the highest concentration tested.
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 544 mg/kg soil dw
Additional information
Two key studies are available to assess the toxicity of the substance to soil macroorganisms, using ta read-across substance (EC Number: 422 -320 -3). This supporting substance is considered adequate for read-across purposes (see IUCLID section 13 for justification).
The first key study is an acute study, performed according to the OECD Guideline 207 with GLP statement, on the earthworm Eisenia foetida in an artificial soil. Following a preliminary range-finding test, 60 earthworms (6 replicates of 10 worms) were exposed to a single nominal concentration of 1000 mg/kg dw of soil for a period of 14 days. The number of mortalities were determined after 7 and 14 days exposure. The 14 -d LC50 for the test material to earthworms based on nominal test concentrations was greater than 1000 mg/kg dw. The NOEC was >= 1000 mg/kg dw.
The second key study is a chronic study, performed according to the OECD Guideline 222 with GLP statement, on the earthworm, Eisenia foetida, in an artificial soil. 40 adult earthworms (4 replicates of 10 worms) were exposed to nominal concentrations of 62.5, 125, 250, 500 and 1000 mg/kg dw of soil for a period of 28 days (4 weeks). Mortality and growth effects (and other sub-lethal effects) was determined after 28 days (4 weeks) of exposure. The adult earthworms were then removed from the soil and effects on reproduction were assessed after a further 28 days (4 weeks). The measured concentration of the test item in the pooled soil sample (1000 mg test item/kg soil dry weight) at test start was 54.4% indicating a distinct loss of the test item caused by the application procedure. Therefore, the results are based on the initial measured concentrations of the test item. The NOEC based on mortality, growth and earthworm reproduction based on initial measured test concentrations was >= 544 mg/kg soil dry weight. The LOEC was greater than 544 mg/kg soil dry weight.
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