Diisopropyl adipate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is ffrom publication

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Final Report on the Safety of test chemical

Author:

Mary Ann Liebert

Year:

1984

Bibliographic source:

jOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY Volume 3, Number 3, 1984

Reference 2

Reference Type:

publication

Title:

Test chemical: Results of all 1982 Sampling with Cover Letter dated 10-22-1984

Author:

NTRL

Year:

1984

Bibliographic source:

NTRL report, OTS00002681, 1984

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute oral toxicity of test chemical in rats

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Diisopropyl adipate

EC Number:

230-072-0

EC Name:

Diisopropyl adipate

Cas Number:

6938-94-9

Molecular formula:

C12H22O4

IUPAC Name:

1,6-bis(propan-2-yl) hexanedioate

Test material form:

liquid

Details on test material:

Test material identity: 6938-94-9/ 230-072-0/ Diisopropyl adipate
Details on test material
IUPAC name: Diisopropyl adipate
Smiles:: O(C(CCCCC(OC(C)C)=O)=O)C(C)C
InChI: 1S/C12H22O4/c1-9(2)15-11(13)7-5-6-8-12(14)16-10(3)4/h9-10H,5-8H2,1-4H3
- Name of test material :Adipic acid
- Molecular formula : C12H22O4
- Molecular weight : 230.302
- Substance type: Organic

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

not specified

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

10(5/sex)

Control animals:

not specified

Details on study design:

Not specified

Statistics:

Not specified

Results and discussion

Preliminary study:

Not specified

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other:

Remarks:

Mortality observed

Mortality:

One female died on day 2 of experement

Clinical signs:

other: Not specified

Gross pathology:

Necropsy findings of this animal were dark and mottled lungs and liver, reddened pylorus, and gas-filled GI tract.
surviving animals showed signs of decreased activity, ataxia, diarrhea, gasping, and urinary incontinence.

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

The acute oral LD50 of test chemical in 5 male and 5 female rats was estimated to be 5000 mg/kg .

Executive summary:

Acute oral toxicity study of test chemical was conducted on 5 male and 5 female Sprague- Dawley rats at the dose concentration of 5000 mg/kg bw. The test chemical was administered via oral route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. One female died on day 2.No clinical signs were observed during 14 days observation period. Necropsy findings were dark and mottled lungs and liver, reddened pylorus, and gas-filled GI tract. surviving animals showed signs of decreased activity, ataxia, diarrhea, gasping, and urinary incontinence. Therefore, LD50 value was considered to be 5000 mg/kg bw, when rats were treated with test chemical via oral route.