Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-897-9 | CAS number: 111-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to other aquatic organisms
Administrative data
- Endpoint:
- toxicity to other aquatic vertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2e: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- To compare the susceptibility of A.mexicanum and X.laevis to toxicants, the 48 h LC50 was determined for 15 chemical compounds, which have been used in comparative studies before (CANTON &ADEMA 1978).For this purpose groups of 10 animals of each species, 3 to 4 weeks after hatching, were exposed for two days to different concentrations of the test compounds in 1-L standardized medium (Dutch Standard Water 1) in covered glass basins. The compounds were added to the water dissolved in distilled water or, if necessary, in acetone, ensuring that no toxic concentrations of acetone were used. The temperature was kept at 20 ± 1oc and the basins were illuminated following a circadic rhythm. During the experiments the organisms were not fed. The 48 h LC50 values were calculated using the method of LITCHFIELD & WILCOXON (1949).
- GLP compliance:
- no
Test material
- Reference substance name:
- Heptan-1-ol
- EC Number:
- 203-897-9
- EC Name:
- Heptan-1-ol
- Cas Number:
- 111-70-6
- Molecular formula:
- C7H16O
- IUPAC Name:
- heptan-1-ol
- Reference substance name:
- heptane-1-ol
- IUPAC Name:
- heptane-1-ol
- Details on test material:
- No data.
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No test surrogate or analogue material was used.
Sampling and analysis
- Analytical monitoring:
- not specified
- Details on sampling:
- No data.
Test solutions
- Vehicle:
- not specified
- Details on test solutions:
- The compounds were added to the water dissolved in distilled water or, if necessary, in acetone, ensuring that no toxic concentrations of acetone were used.
Test organisms
- Test organisms (species):
- other: Ambystoma mexicanum and Xenopus laevis
- Details on test organisms:
- Concerning A. mexicanum, the following procedures were applied to come to a satisfactorial culture method :
a.Cold temperature shock : Both sexes were exposed to a slight increase of water temperature (20 -23°C) during 24 h, followed by a sudden fall in water-temperature (23 - 10-12°C) After a certain period of time, varying from 1 day to two weeks, the water temperature was gradually increased to 20 C.
b.Hormonal stimulation of the female : Females were injected intraperitoneally with different amount of gonadotrophic hormones (Pregnyl(R), Organon 75 I.U., 400 I.U. and 800 I.U.) and subsequently placed with untreated males.
c.Hormonal stimulation of the male : Males were injected intraperitoneally with 75 I.U. or 400 I.U. of gonadotrophic hormones (Pregnyl(R), Organon) and subsequently brought together with untreated females.
d.Hormonal stimulation of both sexes, involving injection with 75 I.U. of the animals on the same day, or injection of the males with 300 I.U. on two successive days and injection of the females with 600 I.U.Pregnyl(R) on the second day.
For this study 3-year-old animals were used, obtained from the University of Utrecht, The Netherlands.
Spawnings of X.laevis were obtained by injecting the male twice with 300 I.U. Pregnyl(R) on two successive days and the females once with 600 I.U.Pregnyl(R) on the second day. The injections have been made into the dorsal lymph sac, piercing the skin of the thigh and the septum between the lymph sacs of the thigh and the back (OCHsE 1948).
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No post exposure observation period was done.
Test conditions
- Hardness:
- No data.
- Test temperature:
- The temperature was kept at 20 ± 1°C.
- pH:
- No data.
- Dissolved oxygen:
- No data.
- Salinity:
- Tests were performed in freshwater.
- Nominal and measured concentrations:
- No data.
- Details on test conditions:
- The basins were illuminated following a circadic rhythm. During the experiments the organisms were not fed.
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 52 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks on result:
- other: A. mexicanum
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 52 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks on result:
- other: X. laevis
- Details on results:
- No more data are guven in the publication.
- Reported statistics and error estimates:
- No data.
Any other information on results incl. tables
No data.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- To compare the susceptibility of A.mexicanum and X.laevis to toxicants, the 48 h LC50 was determined for 15 chemical compounds, which have been used in comparative studies before (CANTON &ADEMA 1978). For this purpose groups of 10 animals of each species, 3 to 4 weeks after hatching, were exposed for two days to different concentrations of the test compounds in 1-L standardized medium (Dutch Standard Water 1) in covered glass basins. During the experiments the organisms were not fed. The 48 h LC50 values were calculated using the method of LITCHFIELD & WILCOXON (1949) and estimated at for A. mexicanum and at for X. laevis.
- Executive summary:
To compare the susceptibility of A.mexicanum and X.laevis to toxicants, the 48 h LC50 was determined for 15 chemical compounds, which have been used in comparative studies before (CANTON &ADEMA 1978). For this purpose groups of 10 animals of each species, 3 to 4 weeks after hatching, were exposed for two days to different concentrations of the test compounds in 1-L standardized medium (Dutch Standard Water 1) in covered glass basins. The compounds were added to the water dissolved in distilled water or, if necessary, in acetone, ensuring that no toxic concentrations of acetone were used. The temperature was kept at 20 ± 1°C and the basins were illuminated following a circadic rhythm. During the experiments the organisms were not fed. The 48 h LC50 values were calculated using the method of LITCHFIELD & WILCOXON (1949) and estimated at for A. mexicanum and at for X. laevis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.