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EC number: 258-981-8 | CAS number: 54112-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14.11.1988-28.11.1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Additol XL 465
- IUPAC Name:
- Additol XL 465
- Test material form:
- solid: particulate/powder
- Details on test material:
- yellow to brown granulate, technical grade
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were kept in groups of 5 in Makrolon cages at 22 ±3 °C and 50 ±20% relative humidity with 12 hours ilumination per day. The acclimatisation period prior to dosing was minimum 5 days. 16 hours before application and 3 - 4 hours thereafter no feed was provided. Water was orvided ad libitum. Animals were individually marked with KMnO4 marks on fur and cages were clearly identifiable.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Doses:
- 2000 mg/kg
concentration: 20%(w/v)
application volume: 10 ml/kg bw - No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality after 14 days observation
- Clinical signs:
- other: Obserced symtoms 4 - 6 h after application: crouch position, drawn-in flanks, irregular breathing (only male), reduced activity, uncoordinated movement (only female). After one day no symptoms were observed.
- Gross pathology:
- without finding
- Other findings:
- no other findings
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 in this study was >2000 mg/kg bw; no mortality was observed.
- Executive summary:
The study on acute oral toxicity of Additol XL 465 (Hoechst name of EC 258-981-8 N,N'-(methylenedi-p-phenylene)bis[hexahydro-2-oxo-1H-azepine-1-carboxamide]) on male and female Wistar-rats results in a LD50 of >2000 mg/kg bw. After application of 2000 mg/kg bw no mortality was observed but slight symptoms.
At the day of application the animals showed symptoms crouch position, drawn-in flanks, irregular breathing (only male), reduced activity, uncoordinated movement (only female). From second day there were no symptoms observed.
No pathologic finding was observed.
The development of body weight was normal.
The result of the study is sufficient for classification.
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