Potassium iodide

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is from peer reviewed journal

Justification for type of information:

Data is from peer reviewed journal

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

Study was conducted to determine the effect of test chemical on Dreissena polymorpha.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

other aquatic mollusc: Dreissena polymorpha

Details on test organisms:

LIFE STAGE : Adult(s)COMMENT : 1.5-2.0 cm

Test type:

static

Water media type:

freshwater

Total exposure duration:

24 h

Hardness:

No data

Test temperature:

20 deg C

pH:

7

Dissolved oxygen:

No data

Salinity:

No data

Nominal and measured concentrations:

No data

Details on test conditions:

No data

Reference substance (positive control):

not specified

Key result

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

226 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: Other details not known

Validity criteria fulfilled:

no

Conclusions:

The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L.

Executive summary:

Study was conducted to determine the effect of test chemical on Dreissena polymorpha. Test conducted under the static system on 1.5-2.0 cm old freshwater Dreissena polymorpha. 24 hrs of exposure period were provided. The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L. Based on the LC50 value, chemical consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.

Description of key information

Study was conducted to determine the effect of test chemical on Dreissena polymorpha. Test conducted under the static system on 1.5-2.0 cm old freshwater Dreissena polymorpha. 24 hrs of exposure period were provided. The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L. Based on the LC50 value, chemical consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

226 mg/L

Additional information

Data available for test chemicals including structurally and functionally similar read across chemical, study has been reviewed to determine the short term toxicity of the test chemical on the growth and mobility of daphnia magna. The studies are as mentioned below:

The first study was conducted to determine the effect of test chemical on Dreissena polymorpha. Test conducted under the static system on 1.5-2.0 cm old freshwater Dreissena polymorpha. 24 hrs of exposure period were provided. The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L. Based on the LC50 value, chemical consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.

 

First study was supported by the second study from experimental report. The study was designed to assess the toxic effects of the test compound on the test Daphnids. Beaker containing 20ml of media with 10 Daphinds. A static procedure was used for the study and it was conducted in compliance with the OECD guideline 202. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 2 mg of the test substance in 20 ml of ADaM’s media. Achieving test concentrations of 100 mg/L, respectively. The test concentrations selected for the study was 100 mg/L. The test vessels used were all glass beaker having the water capacity of 25ml, in each vessel 10 daphnia were incorporated. Observations (immobility, pH, Temperature, dissolved oxygen content) were recorded after 24 and 48hours of the start of the experiment. Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test chemical on freshwater daphnia magna was determine to be 100 mg/L. This value indicates that the substance is likely to be nonhazardous to aquatic invertebrate and cannot be classified as per the CLP criteria.

 

Similar study was conducted to investigate the effect of test chemical on the growth of daphnia magna. Study conducted according to the ISO 6341 15 "Water quality – Determination of the inhibition of the mobility of Daphnia magna Straus (Cladocera, Crustacea)". Test chemical exposed with the daphnia magna for 48 hrs. After the exposure of test chemical with the daphnia magna for 48 hrs, EC0 no effect were observed on the mobility at the concentration 940 mg/l. Thus on the basis of above result it can be concluded that the chemical was nontoxic and not classified as per the CLP classification criteria.

 

Thus based on the above results, chemical consider to be nontoxic and thus not classified as per the CLP classification criteria.