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EC number: 211-623-4 | CAS number: 675-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 24.5 mg/m³
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
- Overall assessment factor (AF):
- 1
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
There are no adequate data regarding the repeated dose toxicity of dichloromethyl(3, 3, 3-trifluoropropyl)silane or its hydrolysis product methyl(3, 3,3-trifluoropropyl)silanediol, therefore data from the other hydrolysis product HCl are considered appropriate to determine local DNELs for the parent substance. Dichloromethyl(3, 3, 3-trifluoropropyl)silane hydrolyses very rapidly in contact with moist air and in contact with tissues to form 2 moles of hydrogen chloride (HCl) and one mole of methyl(3, 3,3-trifluoropropyl)silanediol. Local effects (corrosion) are therefore influenced by the formation of HCl.
Hydrogen chloride (HCl)
An EU long-term inhalation Occupational Exposure Limit (OEL) has been set for HCl as 8 mg/m³(8 h TWA) in Commission Directive 2000/39/EC.
The SIDS Initial Assessment Report (SIAR) for HCl describes a systemic NOAEL of 20 ppm from a 90-day repeated dose inhalation study (OECD, 2002). However, since the NOAEL for local effects in the same study was 10 ppm it is considered by the author of this CSR that the observed effects at 20 ppm were secondary to corrosion.
The OECD SIAR (2002) reports the following:
For repeated dose toxicity, 13 inhalation and 7 oral dose studies has been reported. Among those, only the inhalation studies reported by CIIT (1984) were reliable. They were performed in compliance with FDA-GLP, and they are considered to be the critical studies for assessment. Four groups of 10 males and 10 females (mice: B6C3F1; rats: SD and F344) individually housed were exposed to hydrogen chloride gas at concentrations of 0, 10, 20 and 50 ppm for 90 days (6 hours/day, 5 days/week). For male and female mice at 50 ppm, a decrease in body weight gain, food consumption and liver weight (male) was noted. For male SD rats at 50 ppm, a decrease in food consumption was observed. For F344 rats, a decrease in body weight gain was observed in males at 50 ppm and a decrease in food consumption was observed in both sexes at 20 and 50 ppm. No biologically significant difference was observed in urinalysis, haematology and serum chemistry. Inflammatory histopathological changes in lips or nasal cavity were observed in B6C3F1 mice and F344 rats above 10 ppm or in SD rats above 20 ppm. In addition, the histopathological examination of reproductive organs (testis, epididymis, prostate, seminal vesicle; ovary, uterus, oviduct, mammary glands) could not find any exposure related effects. The NOAEL for repeated dose inhalation toxicity, except for the local effects of irritation, is considered to be 20 ppm for rats and mice.
It is therefore considered appropriate to use the existing EU OEL for HCl as the starting point to quantify local DNELs for dichloromethyl(3, 3, 3-trifluoropropyl)silane.
Long-term exposure –Local effects:
Inhalation DNEL:
Since each mole of dichloromethyl(3, 3, 3-trifluoropropyl)silane (molecular weight 211.1 g/mol) produces two moles of HCl (molecular weight 36.46), it is appropriate to calculate the starting concentration of dichloromethyl(3, 3, 3-trifluoropropyl)silane that would result in an exposure concentration of 8 mg/m³ HCl, assuming complete hydrolysis.
The equivalent exposure level expressed as parent dichloromethyl(3, 3, 3-trifluoropropyl)silane is calculated as (MW (HCl) = 36.46 g/mol MW dichloromethyl(3, 3, 3-trifluoropropyl)silane = 211.1 g/mol):
Amount HCl produced by 1 mole dichloromethyl(3, 3, 3-trifluoropropyl)silane= 2 x 36.46 g/mol=68.92 g. Concentration of dichloromethyl(3, 3, 3-trifluoropropyl)silane required to produce 8 mg/m³ HCl= (211.1/ 68.92)*8= 24.50 mg/m³.
No additional assessment factors are applied to the OEL.
Inhalation DNEL (Long-term exposure - local effects, worker) : 24.50 mg/m³
Dermal DNEL: No suitable quantitative data are available.
Long term exposure – Systemic effects
Because of the corrosivity of the substance, the DNEL for local effects is considered sufficiently protective against potential systemic effects.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
There is no potential for exposure of consumers via any route to dichloromethyl(3, 3, 3 -trifluoropropyl)silane, therefore DNELs for consumers are not calculated.
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