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Diss Factsheets
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EC number: 219-323-5 | CAS number: 2414-98-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study based on national / international standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Fed. Reg. 38, No. 187, § 1500.42 (Eye) P. 27019 of 27 Sep. 1973
- GLP compliance:
- no
- Remarks:
- not yet stipulated at that time
Test material
- Reference substance name:
- Magnesium ethanolate
- EC Number:
- 219-323-5
- EC Name:
- Magnesium ethanolate
- Cas Number:
- 2414-98-4
- Molecular formula:
- C2H6O.1/2Mg
- IUPAC Name:
- magnesium ethanolate
- Details on test material:
- - Name of test material (as cited in study report): Magnesium ethylate
- Molecular formula (if other than submission substance): Mg(OC2H5)2
- Molecular weight (if other than submission substance): 114.43
- Substance type: organometallic
- Physical state: solid
- Analytical purity: no data
- Lot/batch No.: no data
- Stability under test conditions: not stable
- Storage condition of test material: Sensitive to hydrolysis and air
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: no data
- Weight at study initiation: 3 - 4 kg
- Housing: stainless-steel cage without litter, 1 animal per cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: > 3 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +-1
- Humidity (%): 55 +-10
- air-conditioned
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg - Duration of treatment / exposure:
- single dose
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM: according to DRAIZE
An irritation index is calculated as follows: The evaluation scores for cornea, iris and conjunctivae are calculated
and added up for each rabbit and at each point in time (24, 48 and 72 hr).
The sum of these findings divided by 18 is the irritation index.
TOOL USED TO ASSESS SCORE: no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 24+48+72 h
- Score:
- 39
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 7 d, assumed to be reversible after 21 d
- Remarks on result:
- other: moderately irritating
- Irritant / corrosive response data:
- 1 hr p.a.: slight reddening and swelling of the conjunctivae and considerable secretion.
24 hr-7 days p.a: purulent coat on the eyes in all rabbits, 3 rabbits with purulent discharge.
7 d p.a.: improvement in the 72 hr findings (7 d irritation index: 22.0), 1 rabbit with no findings (not shown).
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes) based on GHS criteria
- Remarks:
- Migrated information: = Category 2 acc. to CLP Regulation EU: 1272/2008/EC, 3.3.
- Conclusions:
- Magnesium ethanolate is rated to be moderately irritating to eye (Draize scoring system), which is compatible with the criteria for Category-2 irritant (corneal opacity >= 1; iritis >= 1, and reversibility within 21 d) [1272/2008/EC, 3.3.]. This corresponds to Category 2A (irritating to eyes) according to OECD GHS.
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