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Diss Factsheets
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EC number: 200-872-4 | CAS number: 75-46-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The substance was not mutagenic in the Salmonella typhimurium (Ames assay), in a gene mutation assay in Chinese hamster ovary (CHO) AS52/XPRT cells (gpt locus), nor in a mammalian gene mutation assay at the TK-locus of L5178Y cells.
The substance was tested in a Drosophila sex-linked recessive lethal (SLRL) test. The study was included in the US EPA Report of the Gene-Tox Program, where the substance could not be classified as positive or negative because of inadequate sample size. The results were considered ambiguous.
The substance was negative in one in vivo mouse micronucleus assay, but positive in another recent in vivo mouse micronucleus study following OECD guideline 474. In the negative test, concentrations up to 500000 ppm were evaluated. In the positive test, no significant effects were observed during exposure up to 30000 ppm in both sexes, while at 300000 ppm a statistically significant test substance-related increase in the frequency of MN-RETs was observed in male mice only, and at the 72-hour time point only.
There are several reliable genetic toxicity tests available for the substance. Reliable in vivo results indicated that the substance did not produce mutations even during high exposure concentrations considered to be upper boundaries of the maximal recommended exposure concentrations for acute and chronic inhalation studies. In an in vivo mouse micronucleus test, no significant effects were observed during exposure up to 30000 ppm in both sexes while at 300000 ppm, a statistically significant test substance related increase in the frequency of MN-RETs was observed in male mice only, and at the 72-hour time point only.
Endpoint Conclusion:
Justification for classification or non-classification
There are several genetic toxicity tests available for the substance. The substance did not produce mutations in bacterial or mammalian cells when tested in cell culture. In vivo results indicated that the substance did not produce mutations even during high exposure concentrations considered to be upper boundaries of the maximal recommended exposure concentrations for acute and chronic inhalation studies. In an in vivo mouse micronucleus test, no significant effects were observed during exposure up to 500000 ppm. In another in vivo mouse micronucleus test, no significant effects were observed during exposure up to 30000 ppm in both sexes, while at 300000 ppm, a statistically significant test substance related increase in the frequency of MN-RETs was observed in male mice only and at the 72-hour time point only. Based on consideration of the entire genetic database and according to the fact that this dose-level is considerably above upper boundaries of the maximal recommended exposure concentrations for acute and chronic inhalation studies, the substance does not need to be classified for mutagenicity according the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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