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EC number: 227-047-1 | CAS number: 5619-04-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 June 2014-07 September 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant study in accordance with EC A.1, OECD 102 and EPA OPPTS 830.7200.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- (1995)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- (1998)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- thermal analysis
- Remarks:
- (differential scanning calorimetry)
Test material
- Reference substance name:
- Methyl DL-serinate hydrochloride
- EC Number:
- 227-047-1
- EC Name:
- Methyl DL-serinate hydrochloride
- Cas Number:
- 5619-04-5
- Molecular formula:
- C4H9NO3.ClH
- IUPAC Name:
- methyl 2-amino-3-hydroxypropanoate hydrochloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): DL-serine Methylester HCl
- Molecular formula: C4H9NO3.HCl
- Molecular weight: 155.58 g/mol
- Description: White crystalline powder
- Storage condition of test material: At room temperature in the dark
- Expiration date of the lot/batch: 14 September 2014
Constituent 1
Results and discussion
Melting / freezing point
- Melting / freezing pt.:
- 137 °C
- Decomposition:
- yes
- Decomp. temp.:
- > 150 °C
- Remarks on result:
- other: Melt. pt in K.: 410. Decomp. temp. in K: 423.
Any other information on results incl. tables
PRELIMINARY TEST WITH TGA
From 170°C upwards the weight of the sample decreased significantly. From 178°C upwards there was an abrupt decrease observed which indicates reaction and/or decomposition. After the experiment, a charred molten residue remained in the sample container and partially upon the lid.
DSC EXPERIMENTS
Experiment 1: An endothermic peak between 120°C and 160°C was observed, probably due to melting of the test substance. The extrapolated onset temperature of the peak was 136.97°C. After the experiment, a charred molten residue remained in the sample container. The change of the colour from white to black indicated reaction and/or decomposition.
Experiment 2: To investigate the peak between 120°C and 160°C a repeated heating cycle was applied.
-With the first heating the extrapolated onset temperature was 132.18°C.
-During cooling a small exothermic peak was observed between 120°C and 130°C due to crystallization of the test substance.
-With the second heating an extrapolated onset temperature of 131.75°C was obtained.
-After the experiment, a charred molten residue remained in the sample container.
Experiment 3: To determine if the endothermic effect was indeed due to melting of the test substance, heating was stopped at 150°C and the residue was visually inspected. Extrapolated onset temperature: 135.99°C. After the experiment, a white molten residue remained in the sample container from which it was concluded that the observed endothermic effect was indeed caused by melting of the substance.
Experiment 4: The temperature program was the same as in Experiment 1 and similar results were obtained. Extrapolated onset of the melting peak: 136.69°C. After the experiment, a charred (black) molten residue remained in the sample container.
The melting temperature of the substance was calculated from the values obtained in Experiment 1 (136.97°C) and Experiment 4 (136.69°C).
Applicant's summary and conclusion
- Conclusions:
- In a GLP-compliant study in accordance with EC A.1, OECD 102 and EPA OPPTS 830.7200 using differential scanning calorimetry, the melting temperature of the substance has been determined as 137°C. Decomposition of the substance started at 150°C.
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