Registration Dossier
Registration Dossier
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EC number: 214-711-0 | CAS number: 1189-08-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited details available. LD50 was cited in Kirk-Othmer which was false (aminal tested was the mouse see original Lawrence WH et al. 1972 instead of the rat which was cited in Kirk-Othmer).
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 972
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-methyltrimethylene dimethacrylate
- EC Number:
- 214-711-0
- EC Name:
- 1-methyltrimethylene dimethacrylate
- Cas Number:
- 1189-08-8
- Molecular formula:
- C12H18O4
- IUPAC Name:
- 4-[(2-methylprop-2-enoyl)oxy]butan-2-yl 2-methylprop-2-enoate
- Details on test material:
- Purity not specified, but commercial grade assumed.
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 1,3-butylene dimethacrylate
Test animals
- Species:
- mouse
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 640 mg/kg bw
- Remarks on result:
- other: Original value: LD50: 16.063 mol/ 10E6 gm (95% confidence limit: 14.335 - 18.005 mol/10E6 gm) i.p., mice
Applicant's summary and conclusion
- Conclusions:
- The acute intraperitoneal LD50 of 1,3-BDDMA is reported to be 3640 mg/kg bw in mice.
- Executive summary:
The acute intraperitoneal LD50 of 1,3-BDDMA is reported to be 3640 mg/kg bw in mice.
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