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EC number: 272-574-2 | CAS number: 68890-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Octopirox forms chelate complex with two and three valent ions like Fe(II), Fe(III), Al(III). If the test organism is dependent from such ions during the test e.g. algae, daphnia, this will influence growth and survival. As these ions mentioned before are ubiquitous in the sewer, the sewage treatment plant and in the environment e.g. river Octopirox forms immediately these chelate complexes. In order to avoid interference with the necessary test conditions in the Guideline tests and to avoid unrealistic test test settings e.g. pronounced toxicity by interference with essential ions, the aquatic ecotoxicity tests were carried out in river water where the ions mentioned above are present. For algae the Octopirox Fe(III) complex had to be tested as otherwise the required growth rate for the test according OECD 201 could not be achieved.
For all three trophic levels (fish, daphnia and algae) are acute and for daphnia and algae are chronic data available. Octopirox is most toxic to daphnia. For daphnia one acute and one chronic study is available. The chronic 21d Daphnia reproduction study is the basis for the PNECaquatic, together with the ErC10 Algae which results in an Application factor of 50. It is important to note that the daphnia study could not have been carried in reconstituted water with ElendtM4 medium as Octopirox would have chelated the essential ions in the nutirent solution. River water was the test medium to overcome the issue described before.For the risk assessment only river water tests were used to ensure comparability.
In Table 6.1-1 the different test results which are most relevant are given. All aquatic studies were carried out with active ingredient (a.i).
Table 6.1-1 Test results from Octopirox - most relevant Acute and Chronic aquatic tests (active ingredient (a.i.))
the Algae test was carried out with the Octopirox Fe(III) complex
Test type |
Test medium |
Species |
Effect |
|
|
Guideline |
Acute fish |
River water |
Danio rerio |
LC50 (96h) |
1.9 |
mg/l |
OECD 203 |
Acute Daphnia |
River water |
Daphnia magna |
EC50 (48h) |
1.8 |
mg/l |
OECD 202 |
Algae |
River water |
Desmodesmus subspicatus |
ErC50 (72h) |
10.8 |
mg/l |
OECD 201 |
Sludge respiration inh |
Tap water |
Non-adapted sludge |
EC50 (3h) |
583 |
mg/l |
OECD 209 |
|
|
|
|
|
|
|
Chronic daphnia |
River water |
Daphnia magna |
NOECrepro (21d) |
0.13 |
mg/L |
OECD 211 |
Chronic Algae |
River water |
Desmodesmus subspicatus |
ErC10 (72h) |
6.3 |
mg/L |
OECD 201 |
Additional information
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