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EC number: 248-502-0 | CAS number: 27503-81-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototoxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 - 18 Apr 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically valid method with positive control, sufficient documentation
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Phototoxicity study in guinea pigs according to the method of Vinson and Borselli (J. Soc. Cosm. Chem., 17, 123-130, 1966) modified by the test facility
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Bezirksregierung Lüneburg, Germany
- Type of method:
- in vivo
- Endpoint addressed:
- skin irritation / corrosion
- Species:
- guinea pig
- Strain:
- other: Pirbright white (Bor:DHPW (SPF))
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. Winkelmann, Borchen, Germany
- Weight at study initiation: 321 - 365 g
- Housing: collective housing up to a maximum of 5 animals per cage (Macrolon type IV); bedding: LIGNOCEL 3/4 Fasern (Rettenmaier&Söhne GmbH + Co., Ellwangen-Holzmühle, Germany)
- Diet: Ssniff-G pellets (Ssniff Spezialdiäten GmbH, Soest, Germany), ad libitum
- Water: drinking water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- dermal
- Vehicle:
- water
- Details on exposure:
- TEST SITE
- Area of exposure: back (divided in four separate areas)
Test group:
Area 1: no application, irradiation only
Areas 2 and 3: test substance (50 and 100%) and irradiation
Area 4: positive control substance and irradiation
Control group:
Area 1: no application
Areas 2 and 3: test substance (50 and 100%)
Area 4: positive control substance
- Type of wrap if used: open application
- Time intervals for shavings: 24 h before test substance application
TEST MATERIAL
- Amount applied: 50 µL
- Concentration: 50% and 100% (undiluted)
- Constant volume or concentration used: yes
IRRADIATION
- 30 min after test substance application, the test animals, but not the control animals, were irradiated:
Stage 1 (UVB-light): using "TL 20 W/12" lamps, duration: 50 s, irradiance: 20.6 W/m², radiant exposure: 0.10 J/cm²
Stage 2 (UVA-light): using "TL 20 W/09" lamps equipped with glass filters to eliminate UVB-irradiation, duration: 26 min, irradiance: 65.8 W/m², radiant exposure: 10.26 J/cm²
USE OF RESTRAINERS FOR PREVENTING INGESTION: yes - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 30 min after test substance application (control and test animals) irradiation was performed for 26.83 min (test animals only)
- Frequency of treatment:
- test substance application and irradiation was performed once
- Post exposure period:
- Observation period: 48 h
Reading time points of dermal irritation: 24 and 48 h after irradiation - Remarks:
- Doses / Concentrations:
50% and 100% (undiluted)
Basis: - No. of animals per sex per dose:
- 10 test animals (total) with irradiation
- Control animals:
- other: concurrent test substance treatment of 5 control animals (total) without irradiation
- Details on study design:
- A range finding study was conducted with four different concentrations of the test substance (10, 25, 50 and 100%). Each concentration was applied for 24 h to a seperate area of skin (ca. 2 cm²) on the shaved back of two animals. The back was left uncovered. Skin reactions were evaluated 24 and 48 h p.a. No skin reactions were observed.
5% solution of CAS 27503-81-7 in 75% aq. ethanol - Examinations:
- Dermal irritation was evaluated according to the following sheme:
Erythema: 0 (no reaction), 1 (scattered mild erythema), 2 (moderate and diffuse erythema), 3 (intense erythema and swelling)
Edema: 0 (no edema), 1 (slight edema), 2 (moderate edema), 3 (severe edema) - Positive control:
- The positive control 8-Methosypsoralen was dissolved in acetone to give a final concentration of 5%. The areas treated with the positive control substance (area 4) showed a phototoxic reaction only in the irradiated test animals. Three and seven test animals showed scattered mild erythema (score 1) at the 24 and 48 h reading time point, respectively.
- Details on results:
- Neither in the areas treated with the test substance (areas 2 and 3) nor in the untreated area (area 1 - negative control) any skin reactions were observed. Thus the test substance at the applied concentrations is not phototoxic.
- Conclusions:
- In a phototoxicity study in guinea pigs no skin reactions were observed in irridiated areas treated with 50% and 100% (undiluted) test substance. Thus, the test substance is not considered to be phototoxic.
Reference
Description of key information
The test substance is not considered to be phototoxic.
Additional information
In a phototoxicity study in guinea pigs no skin reactions were observed in irridiated areas treated with 50 % and 100 % (undiluted) test substance. Thus, the test substance is not considered to be phototoxic.
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