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EC number: 203-479-6 | CAS number: 107-29-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP study and not according to a recent international test guideline but according to a US regulation. The results are well documented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.42
- GLP compliance:
- no
- Remarks:
- Study from 1974
Test material
- Reference substance name:
- Acetaldehyde oxime
- EC Number:
- 203-479-6
- EC Name:
- Acetaldehyde oxime
- Cas Number:
- 107-29-9
- Molecular formula:
- C2H5NO
- IUPAC Name:
- acetaldehyde oxime
- Details on test material:
- - Test material: 50% AAO
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
Young adult albino rabbits, selected from healthy, acclimated animals
Test system
- Controls:
- no
- Observation period (in vivo):
- 72 h - Ocular reactions were observed and recorded at 24, 48 and 72 h after instillation of the test material.
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- No washout
SCORING SYSTEM: very similar to DRAIZE
Results and discussion
In vivo
- Irritant / corrosive response data:
- The test material produced corneal effects in 5 of the animals, iridial effects in 3 of the animals and conjunctival effects in all 6. None of these effects cleared by the 72 h observation period.
Any other information on results incl. tables
Rabbit |
|
Tissue |
24 h |
48 h |
72 h |
1 |
A |
Cornea opacity |
1 |
1 |
1 |
|
B |
Cornea Area |
4 |
4 |
4 |
|
|
(1) Cornea Total = (AxB) x 5 |
20 |
20 |
20 |
|
C |
Iris |
2 |
1 |
1 |
|
|
(2) Iris Total = (C) x 5 |
10 |
5 |
5 |
|
D |
Conjunctiva Redness |
1 |
2 |
2 |
|
E |
Conjunctiva Chemosis |
3 |
3 |
2 |
|
F |
Conjunctiva discharge |
3 |
3 |
3 |
|
|
(3) Conjunctiva Total = (D+E+F) x 2 |
14 |
16 |
14 |
|
|
Totals Added = (1+2+3) |
44 |
41 |
39 |
|
|
|
|
|
|
2 |
A |
Cornea opacity |
1 |
1 |
1 |
|
B |
Cornea Area |
4 |
4 |
4 |
|
|
(1) Cornea Total = (AxB) x 5 |
20 |
20 |
20 |
|
C |
Iris |
0 |
0 |
0 |
|
|
(2) Iris Total = (C) x 5 |
0 |
0 |
0 |
|
D |
Conjunctiva Redness |
1 |
2 |
2 |
|
E |
Conjunctiva Chemosis |
2 |
2 |
1 |
|
F |
Conjunctiva discharge |
3 |
3 |
3 |
|
|
(3) Conjunctiva Total = (D+E+F) x 2 |
12 |
14 |
12 |
|
|
Totals Added = (1+2+3) |
32 |
34 |
32 |
|
|
|
|
|
|
3 |
A |
Cornea opacity |
1 |
1 |
1 |
|
B |
Cornea Area |
4 |
2 |
2 |
|
|
(1) Cornea Total = (AxB) x 5 |
20 |
10 |
10 |
|
C |
Iris |
1 |
0 |
0 |
|
|
(2) Iris Total = (C) x 5 |
5 |
0 |
0 |
|
D |
Conjunctiva Redness |
2 |
2 |
2 |
|
E |
Conjunctiva Chemosis |
3 |
2 |
2 |
|
F |
Conjunctiva discharge |
3 |
2 |
2 |
|
|
(3) Conjunctiva Total = (D+E+F) x 2 |
16 |
12 |
12 |
|
|
Totals Added = (1+2+3) |
41 |
22 |
22 |
|
|
|
|
|
|
4 |
A |
Cornea opacity |
1 |
1 |
1 |
|
B |
Cornea Area |
4 |
4 |
4 |
|
|
(1) Cornea Total = (AxB) x 5 |
20 |
20 |
20 |
|
C |
Iris |
0 |
0 |
0 |
|
|
(2) Iris Total = (C) x 5 |
0 |
0 |
0 |
|
D |
Conjunctiva Redness |
1 |
3 |
2 |
|
E |
Conjunctiva Chemosis |
3 |
4 |
3 |
|
F |
Conjunctiva discharge |
3 |
3 |
3 |
|
|
(3) Conjunctiva Total = (D+E+F) x 2 |
14 |
20 |
16 |
|
|
Totals Added = (1+2+3) |
34 |
40 |
36 |
|
|
|
|
|
|
5 |
A |
Cornea opacity |
2 |
2 |
1 |
|
B |
Cornea Area |
4 |
4 |
4 |
|
|
(1) Cornea Total = (AxB) x 5 |
40 |
40 |
20 |
|
C |
Iris |
2 |
1 |
0 |
|
|
(2) Iris Total = (C) x 5 |
10 |
5 |
0 |
|
D |
Conjunctiva Redness |
2 |
2 |
1 |
|
E |
Conjunctiva Chemosis |
2 |
2 |
1 |
|
F |
Conjunctiva discharge |
3 |
2 |
2 |
|
|
(3) Conjunctiva Total = (D+E+F) x 2 |
14 |
12 |
8 |
|
|
Totals Added = (1+2+3) |
64 |
57 |
28 |
|
|
|
|
|
|
6 |
A |
Cornea opacity |
0 |
0 |
0 |
|
B |
Cornea Area |
0 |
0 |
0 |
|
|
(1) Cornea Total = (AxB) x 5 |
0 |
0 |
0 |
|
C |
Iris |
0 |
0 |
0 |
|
|
(2) Iris Total = (C) x 5 |
0 |
0 |
0 |
|
D |
Conjunctiva Redness |
2 |
2 |
2 |
|
E |
Conjunctiva Chemosis |
2 |
2 |
1 |
|
F |
Conjunctiva discharge |
3 |
2 |
1 |
|
|
(3) Conjunctiva Total = (D+E+F) x 2 |
14 |
12 |
8 |
|
|
Totals Added = (1+2+3) |
14 |
12 |
8 |
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Conclusions:
- On the basis of the data the test material is a severe irritant to the eye.
- Executive summary:
The test material produced corneal effects in 5 of the animals, iridial effects in 3 of the animals and conjunctival effects in all 6. None of these effects cleared by the 72 h observation period.
Rabbits were not observed after 21 days, so it cannot be concluded if the observed effects are reversible or not.
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