Decan-4-olide

Toxicity to aquatic algae and cyanobacteria

Description of key information

Acute endpoint:

EU Method C3, OECD Guideline 201, GLP, Key study, validity 1:

72 h-ErC50 = 37.2 mg/L

Chronic endpoint:

EU Method C3, OECD Guideline 201, GLP, Key study, validity 1:

72 h-ErC10 = 11.2 mg/L

Key value for chemical safety assessment

EC50 for freshwater algae:

37.2 mg/L

EC10 or NOEC for freshwater algae:

11.2 mg/L

Additional information

γ-decalactone is a linear saturated 4-hydroxycarboxylic acid derived-lactone with 10 carbons.

The influence of Gamma Decalactone on the growth of the freshwater green algae Pseudokirchneriella subcapitata was assessed in a static concentration-response test. The 72-hour E_yC₅₀was calculated to be 12.2 mg test item/L and the 72-hour E_rC₅₀value was calculated to be 37.2 mg test item/L. The 72-hour NOE_yC was determined to be < 1.45 mg test item/L and the associated 72-hour LOE_yC was 1.45 mg test item/L. The 72-hour NOE_rC was determined to be 14.7 mg test item/L and the associated 72-hour LOE_rC was 47.9 mg test item/L.

Other data are available to assess the toxicity to aquatic algae of three structurally similar compounds of aliphatic lactones: γ-nonalactone, γ-decalactone and γ-undecalactone. These data are not used to support the experimental algae study performed on γ-decalactone but are used to support the read-across strategy between these three substances, as mentionned in the Read-across Justification in Section 13.