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EC number: 204-514-8 | CAS number: 122-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study in accordance with principles similar to those of relevant OECD TG 401
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4'-methylacetophenone
- EC Number:
- 204-514-8
- EC Name:
- 4'-methylacetophenone
- Cas Number:
- 122-00-9
- Molecular formula:
- C9H10O
- IUPAC Name:
- 1-(4-methylphenyl)ethanone
- Details on test material:
- - Name of test material (as cited in study report): RIFM-UF-P70
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not reported
- Age at study initiation: not reported
- Weight at study initiation: 150-208 g
- Fasting period before study: 16 hour
- Housing: in stock cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.6, 0.9, 1.4, 2.0, 3.0 g/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily, at the beginning and at the end
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology. - Statistics:
- At the end of the observation period, the acute oral median lethal doses (LD50) of the test materials were calculated using the techniques of Weil, Thompson, and Thompson and Weil.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 400 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 100 - 1 700
- Mortality:
- In the low-dose group, no animal died during the observation period of 14 days. In 0.9 g/kg bw dose group, one rat male died on day two following oral (gavage) exposure. In 1.4 g/kg bw dose group, one rat male died on day two and one rat female died on day three following oral (gavage) exposure. In 2.0 g/kg bw dose group, two rats males and one female died on day three following oral (gavage) exposure. In 3.0 g/kg bw dose group, two rats males died on day two and two rats females died on day one and on day three following oral (gavage) exposure.
- Clinical signs:
- In dose groups from 0.6 to 1.4 g/kg bw, hypoactivity, muscular weakness and ruffed fur were observed, whereas in dose group of 2.0 g/kg bw, additionally diarrhea and in dose group of 3.0 g/kg bw, prostration were observed.
- Gross pathology:
- Necropsy of the animals that died revealed pale livers and hemorrhages in the stomachs. Hemorrhages were also noted at sacrifice in the stomach of one animal (1.4 g/kg level). No other gross pathologic alterations were noted.
Any other information on results incl. tables
Test material: RIFM-UF-P70
Acute Oral Toxicity – Albino Rats
Mortality and Body Weight Data
Dose (g/kg) |
Animal Number and Sex |
Individual Body Weight (g) Test Day Number: |
Number Dead/Number Tested |
Percent Dead |
|
0 |
14 |
||||
0.6 |
1-M |
201 |
226 |
0/4 |
0 |
2-M |
200 |
238 |
|||
3-F |
173 |
228 |
|||
4-F |
196 |
252 |
|||
|
|
|
|
|
|
0.9 |
5-M |
164 |
246 |
1/4 |
25 |
6-M |
186 |
(2 days) |
|||
7-F |
151 |
180 |
|||
8-F |
171 |
214 |
|||
|
|
|
|
|
|
1.4 |
9-M |
165 |
271 |
2/4 |
50 |
10-M |
186 |
(2 days) |
|||
11-F |
174 |
196 |
|||
12-F |
180 |
(3 days) |
|||
|
|
|
|
|
|
2.0 |
13-M |
204 |
(3 days) |
3/4 |
75 |
14-M |
202 |
(3 days) |
|||
15-F |
153 |
(3 days) |
|||
16-F |
162 |
212 |
|||
|
|
|
|
|
|
3.0 |
17-M |
198 |
(2 days) |
4/4 |
100 |
18-M |
194 |
(2 days) |
|||
19-F |
173 |
(6-22 hours) |
|||
20-F |
168 |
(3 days) |
Test material: RIFM-UF-P70
Acute Oral Toxicity – Albino Rats
Summary of Reactions
Dose (g/kg) |
Reaction |
Time of Onset Following Dose Administration |
Duration of Reaction |
Time of Death Following Dose Administration |
0.6 |
Hypoactivity |
½ hour |
2 days |
- |
Muscular weakness |
2 hours |
1 day |
||
Ruffed fur |
6-22 hours |
1 day |
||
|
|
|
|
|
0.9 |
Hypoactivity |
½ hour |
3 days |
2 days |
Muscular weakness |
2 hours |
2 days |
||
Ruffed fur |
6-22 hours |
2 days |
||
|
|
|
|
|
1.4 |
Hypoactivity |
½ hour |
5 days |
3 days |
Muscular weakness |
2 hours |
3 days |
||
Ruffed fur |
2 hours |
5 days |
||
Diarrhea |
2 hours |
2 days |
||
|
|
|
|
|
3.0 |
Hypoactivity |
½ hour |
Until death |
6 hours – 3 days |
Muscular weakness |
2 hours |
|||
Ruffed fur |
2 hours |
|||
Diarrhea |
2 hours |
|||
Prostration |
5 hours |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance was acutely toxic to rats in an acute oral toxicity test with a LD50 value of 1400 mg/kg bw. The substance is classified into Acute Toxicity Category IV according to CLP.
- Executive summary:
The acute oral toxicity of the test substance 4'-methylacetophenone was studied in a non-GLP test according to principles slightly deviating from those of current guidelines. Groups of four animals (two males and two females) were exposed to single oral (gavage) doses of 0.6, 0.9, 1.4, 2.0 and 3.0 g/kg bw. Animals were observed during a period of 14 days. No mortality was observed in the low dose group, whereas one, two, three and four animals died respectively in 0.9, 1.4, 2.0 and 3.0 g/kg bw dose groups. The LD50 value was 1.4 g/kg bw with a standard deviation of 0.3 g/kg bw. Hypoactivity, muscular weakness and ruffed fur were observed in all dose groups, whereas diarrhea was observed additionally in 2.0 and 3.0 g/kg bw dose groups and prostration only in 3.0 g/kg dose group.
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